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Abstract
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Article Information:
Synthesis and Antimicrobial Ctivity of 3-(4-(4-chlorobenzyloxy)phenyl)-1-phenyl-5-(2-chlorophenyl) Pyrazoline (3) on E. coli in Mice
Adel K. Khider, Farouq E. Hawaiz, Sarwen O. Taha and Mohammed S. Ahmed
Corresponding Author: Adel Kamal Khider
Submitted: 2011 May, 02
Accepted: 2011 June, 10
Published: 2011 August, 30 |
Abstract:
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The in vivo antimicrobial activity of synthesized compound Pyrazoline 3-(4-(4-chlorobenzyloxy)
phenyl)-1-phenyl-5-(2-chlorophenyl) pyrazoline (3) against E. coli ATCC25922 strain was investigated. E. coli
ATCC25922 strain was inhibited at concentration of 400 μg/mL. Acute Toxicity of pyrasoline, cleared that all
treated mice with 400 μg/mL increase the survival time, and no significant differences of mortality and behavior
of animals within a week could be seen between pyrasoline treated group and control group. Twelve days after
infection, all immunological indicators in the blood were increased for infected mice, while for infected and
treated was the same as day seven. Sixteen days from infection all immunological parameters for infected mice
were increased, while for infected and treated group was decreased. The remaining mice infected with bacteria
alone died. Survival rate was observed in the group of mice infected and treated with tested chemical compound.
Key words: Antibiotic resistant, antimicrobial, E. coli, in vivo, pathogenic bacteria, pyrazoline,
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Abstract
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Cite this Reference:
Adel K. Khider, Farouq E. Hawaiz, Sarwen O. Taha and Mohammed S. Ahmed, . Synthesis and Antimicrobial Ctivity of 3-(4-(4-chlorobenzyloxy)phenyl)-1-phenyl-5-(2-chlorophenyl) Pyrazoline (3) on E. coli in Mice. Asian Journal of Medical Sciences, (4): 158-163.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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