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    Abstract
2013 (Vol. 5, Issue: 01)
Article Information:

A Validated RP-LC Method for the Determination of Erythromycin an Oxime and Related Substances

Zhiling Cao, Bing Liu, Weiwei Liu, Yinxing SU, Wenming Bo and Guowei Yao
Corresponding Author:  Zhiling Cao 

Key words:  Column liquid chromatography, erythromycin an oxime, macrolide antibiotics, related substance, , ,
Vol. 5 , (01): 68-71
Submitted Accepted Published
October 09, 2012 November 23, 2012 January 15, 2013
Abstract:

A liquid chromatographic method was developed and validated for the determination of erythromycin an oxime and related substances. The chromatographic analysis was performed on Inertsil C18 ODS column, using the phosphate buffer solution (0.02 M, pH 6.5)-acetonitrile (40:60, V/V) as the mobile phase. Wavelength of the UV detector was 215 nm. All four related substances, including Z isomer of erythromycin A oxime, erythromycin A, erythromycin A-6, 9-hemiketal and erythromycin A-6, 9-9, 12-spiroketal were separated and determined under isocratic elution. The effect of pH and the concentration of mobile phase on separation were studied. The developed method was successfully applied to the analysis of erythromycin an oxime in commercial formulation.
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  Cite this Reference:
Zhiling Cao, Bing Liu, Weiwei Liu, Yinxing SU, Wenming Bo and Guowei Yao , 2013. A Validated RP-LC Method for the Determination of Erythromycin an Oxime and Related Substances.  Advance Journal of Food Science and Technology, 5(01): 68-71.
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ISSN (Online):  2042-4876
ISSN (Print):   2042-4868
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