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    Abstract
2013 (Vol. 5, Issue: 10)
Article Information:

Research on Water Bath Dynamic Cross-linking Properties of Bone Scaffold Made of Gelatin and Sodium Alginate

Lulu Zheng, Yuanyuan Liu, Feifei Yan, Weihua Chen, Fuhua Zhang and Qingxi Hu
Corresponding Author:  Yuanyuan Liu 

Key words:  Cross-linking, Ca2+ ions ., mechanical properties, water bath dynamic, , ,
Vol. 5 , (10): 1318-1321
Submitted Accepted Published
May 16, 2013 July 05, 2013 October 05, 2013
Abstract:

This study presents a novel water bath dynamic cross-linking method which involves cross-linking process when the bone scaffold is being manufactured. Biomaterial possesses good biocompatibility, but possesses poor mechanical properties. Thus, the uncross-linked bone scaffold usually degrades rapidly, contracts easily and canít meet the requirements of scaffold for tissue engineering. After being cross-linked by Ca2+ ions, scaffold made of Gelatin and Sodium Alginate (SA), one kind of gel-type scaffolds, can present much better mechanical properties. However, Ca2+ ions can react with SA solution and the gel can limit the flowing of Ca2+ ions in the entire system, hence making cross-linking process uneven for the inner part. Applying the novel approach, the designed experiment verifies the scaffold can posses higher porosity, contain more water, has lower degradation rate and better mechanical properties.
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  Cite this Reference:
Lulu Zheng, Yuanyuan Liu, Feifei Yan, Weihua Chen, Fuhua Zhang and Qingxi Hu, 2013. Research on Water Bath Dynamic Cross-linking Properties of Bone Scaffold Made of Gelatin and Sodium Alginate.  Advance Journal of Food Science and Technology, 5(10): 1318-1321.
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ISSN (Online):  2042-4876
ISSN (Print):   2042-4868
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