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Abstract
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Article Information:
Pancreatic Lipase Inhibitory Effects of Mangosteen Pericarps
Xinjie Lin, Baojun Xu and Liu Rui
Corresponding Author: Baojun Xu
Submitted: September 18, 2012
Accepted: October 30, 2012
Published: March 10, 2014 |
Abstract:
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Pancreatic lipase plays a key role in the digestion and absorption of lipids, inhibition of Pancreatic Lipase (PL) is considered as a new approach to obesity treatment. The objective of the present study was to find PL inhibitors from natural food sources. Eighteen natural food products sampled from local supermarkets in Zhuhai were tested for PL inhibitory activity using a copper-soap photometric method. Among the samples tested, the crude extracts from mangosteen pericarp, lemon pulp, celery, cucumber and dry longan were found to be able to suppress the PL activity to different extents, while dry red chili, fresh green chili and dry clove exhibited a promotion effect on the PL. Shiitake mushroom, green bell pepper, lemon peel and spices (ginger, oregano leaf, bay leaf, cinnamon and dry tangerine) showed no significant influence either on the inhibition or promotion. The crude extract of mangosteen pericarp was further fractioned to trace active fractions. It was found that the n-butanol fraction was the major contributor to the PL-inhibitory effect of mangosteen pericarp and the inhibition rate was 43.9% at the concentration of 1 mg/mL, the IC50 value was 0.918 mg/mL. Mangosteen pericarp is worthy of utilization as functional food constituents for the prevention and treatment of obesity.
Key words: Mangosteen pericarp, natural food products, obesity, pancreatic lipase, , ,
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Cite this Reference:
Xinjie Lin, Baojun Xu and Liu Rui, . Pancreatic Lipase Inhibitory Effects of Mangosteen Pericarps. Advance Journal of Food Science and Technology, (3): 284-291.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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