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Abstract
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Article Information:
Research on the Capsule of Ganoderma lucidum and Zizhiphi spinozae Improving the Sleep in Mice
Ya-Li Dang, Xue-Qian Wu, Ai-Ying Xie and Zhong-Jian Zhan
Corresponding Author: Zhong-Jian Zhang
Submitted: November 04, 2013
Accepted: November 28, 2013
Published: March 10, 2014 |
Abstract:
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Nowadays, more and more people are suffering from insomnia with difficulty in initiating or maintaining sleep. Ganoderma lucidum (G. lucidum) and Ziziphi spinosae (Z. Spinosae) are conventional herbal drugs in traditional Chinese medicine and they have been used lonely for the treatment of insomnia. In the present study, G. lucidum and Z. spinosae were combined and the active fractions were extracted to make the capsule. Furthermore, their effect on improving sleep in mice was investigated. The functional compositions of the capsule were polysaccharide, total flavone, spinosin and triterpenoid, with the content being 12.08, 1.35, 0.67 and 1.50 g/100 g, respectively. The effect of the capsule on improving sleep in mice was studied. Results showed no effects on the sleep induced directly in mice assessed with the loss-of-righting reflex even at the high dose of 450, 1350 mg/kg/day. However, the capsule significantly decreased sleep latency and increased sleeping time and prolonged sleeping time induced by pentobarbital sodium at high doses. In conclusion, the capsule of G. lucidum and Z. spinozae combined had the function of improving sleep
Key words: Functional composition, Ganoderma lucidum, pentobarbital sleep, Zizhiphi spinozae, , ,
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Cite this Reference:
Ya-Li Dang, Xue-Qian Wu, Ai-Ying Xie and Zhong-Jian Zhan, . Research on the Capsule of Ganoderma lucidum and Zizhiphi spinozae Improving the Sleep in Mice. Advance Journal of Food Science and Technology, (3): 378-382.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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