Abstract
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Article Information:
Anti-hepatocarcinoma Effects of a Food Additive Resveratrol Nanosuspension Against Human HepG2 Cells
Shi-Qiong Luo, Wen-Liang Lu, Yi-Fei Wang and Zhi-Ping Wang
Corresponding Author: Yi-Fei Wang
Submitted: December 10, 2014
Accepted: January 8, 2015
Published: May 15, 2015 |
Abstract:
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Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Resveratrol (Res), a major symbol ingredient in red grapes and peanuts, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Res-nanosuspension (Res-NS) composed of Res and poloxamer 188 was prepared by high pressure homogenization technique. The in vitro anti-hepatocarcinoma effects of Res-NS relative to efficacy of bulk Res were evaluated. The particle size and zeta potential of Res-NS were 159.4 nm and -2.1 mV, respectively. MTT assay showed that Res-NS effectively inhibited the proliferation of HepG2 cells and the corresponding IC50 values of Res-NS and bulk Res were 2.91 and 7.13 &mug/mL. These results suggest that the delivery of Res-NS is a promising approach for treating tumors.
Key words: Antitumor activity, cytotoxicity, HepG2 cells, nanosuspension, resveratrol, ,
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Cite this Reference:
Shi-Qiong Luo, Wen-Liang Lu, Yi-Fei Wang and Zhi-Ping Wang, . Anti-hepatocarcinoma Effects of a Food Additive Resveratrol Nanosuspension Against Human HepG2 Cells. Advance Journal of Food Science and Technology, (3): 210-213.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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