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Abstract
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Article Information:
The Anticoagulation Effects of Glycosaminoglycan from Mactra veneriformis
Yue Wang, Haixia Wang, Qingman Cui
Corresponding Author: Chunying Yuan
Submitted: January 8, 2015
Accepted: February 11, 2015
Published: July 20, 2015 |
Abstract:
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In this study, the anticoagulation effect of glycosaminoglycan from Mactra veneriformis was studied. The results showed that glycosaminoglycan mainly exerted anticoagulation via antithrombin III. Glycosaminoglycan could passivate the function of heparin cofactor II inhibiting thrombin activity. Glycosaminoglycan significantly reduced the activities of coagulation factor II, V, VII, X, VIII, IX, XI, XII as well as fibrinogen content in the plasma (p<0.05, p<0.01). Besides, glycosaminoglycan could extend blood recalcification time in rats by shielding Ca2+ in plasma and significantly reduced Ca2+ concentration in rats and mice serum (p<0.05, p<0.01). Glycosaminoglycan reduced the Ca2+ concentration in serum in a more intensive way than that of heparin sodium (p<0.05, p<0.01).
Key words: Anticoagulation effect, glycosaminoglycan, Mactra veneriformis, , , ,
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Cite this Reference:
Yue Wang, Haixia Wang, Qingman Cui, . The Anticoagulation Effects of Glycosaminoglycan from Mactra veneriformis. Advance Journal of Food Science and Technology, (12): 878-882.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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