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Abstract
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Article Information:
Evaluation of Urinary Tubular Enzymes as Screening Markers of Renal Dysfunction in Patients Suffering from Diabetes Mellitus
Wilfred. K. Gatua, Joseph N. Makumi, Eliud M. Njagi, Christine S. Kigondu, Seth O. Mcligeyo and Stanley K. Waithaka
Corresponding Author: Wilfred Kimani Gatua
Submitted: 2010 December, 29
Accepted: 2011 February, 07
Published: 2011 June, 20 |
Abstract:
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To determine the relationship between sub clinical kidney injury caused by diabetes mellitus and the
levels of urinary enzymes; N-acetyl-$-D-glucosaminidase, lactate dehydrogenase, alkaline phosphatase and
gamma glutamyl transferase in relation to urinary concentration of microprotein, serum urea and creatinine.
The study subjects comprised 251 patients with Diabetes Mellitus (cases), and 73 healthy individuals (control
group). The cases were further subdivided into those with normoproteinuria, microproteinuria and kidney
failure. Glomerular function was studied by urinary levels of protein (U.mp), serum urea and creatinine while
proximal tubular structural integrity was studied by determining the activities of the enzymes U.ALP, U.NAG,
U.γ-GT, and U.LDH. Compared with healthy individuals, diabetic patients with normoproteinuria excreted
significantly high levels of U.ALP, U.LDH, U.γ-GT, and U.NAG (p<0.05). Patients with kidney impairment
excreted high levels of the enzymes and urinary microprotein compared to healthy individuals and diabetic
patients without kidney failure. Diabetes mellitus leads to subclinical renal injury; that urinary excretion of
U.ALP, U.LDH, U.γ-GT, and U.NAG could be useful biomarkers for proximal tubular injury. These results
suggest that site-specific urinary biochemical markers provide valuable information about early renal proximal
tubular insult that ultimately may precede glomerular permeability in subjects with diabetes mellitus.
Key words: Diabetes mellitus, glomerular function, kidney failure, tubular integrity, urinary tubular enzymes, ,
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Cite this Reference:
Wilfred. K. Gatua, Joseph N. Makumi, Eliud M. Njagi, Christine S. Kigondu, Seth O. Mcligeyo and Stanley K. Waithaka, . Evaluation of Urinary Tubular Enzymes as Screening Markers of Renal Dysfunction in Patients Suffering from Diabetes Mellitus. Asian Journal of Medical Sciences, (3): 84-90.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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