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Abstract
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Article Information:
Spathodea Campanulata: an Experimental Evaluation of the Analgesic and Anti-inflammatory Properties of a Traditional Remedy
Emmanuel. E Ilodigwe and Peter. A. Akah
Corresponding Author: Peter A. Akah
Submitted: 2009 June, 17
Accepted: 2009 June, 25
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Abstract:
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The analgesic and anti-inflammatory potentials of the ethanol leaf extract of Spathodea campanulata,
a Nigerian traditional medicinal plant was studied using cold, thermal and chemical-induced pain models, and
carrageenan-induced acute inflammation in rats. The acute toxicity and the phytochemical constituents of the
extract were also determined. The results showed that the extract (250-1000 mg/kg) significantly (P<0.05) and
dose-dependently prolonged the pain reaction times in hot-plate and tail flick pain models, and reduced acetic
acid –induced writhing. The extract demonstrated significant anti-inflamm atory activity against acute
inflammation induced by carrageenan. The estimated LD50 of the extract was 4500 mg/kg. Phytochemical
analysis revealed the presence of tannins, saponins, anthraquinone glycosides and flavonoids. These findings
indicate that the leaf extract of Spathodea campanulata has both analgesic and anti- inflammatory properties
and could be beneficial in alleviating painful inflammatory conditions
Key words: Analgesic, antiinflammatory, carrageenan, native medicine, Spathodea campanulata, rodents,
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Cite this Reference:
Emmanuel. E Ilodigwe and Peter. A. Akah, . Spathodea Campanulata: an Experimental Evaluation of the Analgesic and Anti-inflammatory Properties of a Traditional Remedy. Asian Journal of Medical Sciences, (2): Page No: 35-38.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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