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2009 (Vol. 1, Issue: 2)
Article Information:

Spathodea Campanulata: an Experimental Evaluation of the Analgesic and Anti-inflammatory Properties of a Traditional Remedy

Emmanuel. E Ilodigwe and Peter. A. Akah
Corresponding Author:  Peter A. Akah 

Key words:  Analgesic, antiinflammatory, carrageenan, native medicine, Spathodea campanulata, rodents,
Vol. 1 , (2): Page No: 35-38
Submitted Accepted Published
2009 June, 17 2009 June, 25
Abstract:

The analgesic and anti-inflammatory potentials of the ethanol leaf extract of Spathodea campanulata, a Nigerian traditional medicinal plant was studied using cold, thermal and chemical-induced pain models, and carrageenan-induced acute inflammation in rats. The acute toxicity and the phytochemical constituents of the extract were also determined. The results showed that the extract (250-1000 mg/kg) significantly (P<0.05) and dose-dependently prolonged the pain reaction times in hot-plate and tail flick pain models, and reduced acetic acid –induced writhing. The extract demonstrated significant anti-inflamm atory activity against acute inflammation induced by carrageenan. The estimated LD50 of the extract was 4500 mg/kg. Phytochemical analysis revealed the presence of tannins, saponins, anthraquinone glycosides and flavonoids. These findings indicate that the leaf extract of Spathodea campanulata has both analgesic and anti- inflammatory properties and could be beneficial in alleviating painful inflammatory conditions
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  Cite this Reference:
Emmanuel. E Ilodigwe and Peter. A. Akah, 2009. Spathodea Campanulata: an Experimental Evaluation of the Analgesic and Anti-inflammatory Properties of a Traditional Remedy.  Asian Journal of Medical Sciences, 1(2): Page No: 35-38.
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