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2011 (Vol. 3, Issue: 6)
Article Information:

Comparative Stabilizing Effects of Some Anticoagulants on Fasting Blood Glucose of Diabetics and Non-diabetics, Determined by Spectrophotometry (Glucose Oxidase)

Nwangwu C.O. Spencer, Josiah J. Sunday, Omage K. Erifeta, O. Georgina, Asuk A. Agbor, Uhunmwangho S. Esosa and O. Jenevieve
Corresponding Author:  Omage K. Erifeta 

Key words:  Anticoagulants, EDTA, fluoride oxalate, glucose oxidase, heparin, plasma glucose,
Vol. 3 , (6): 234-236
Submitted Accepted Published
2011 September, 21 2011 November, 16
Abstract:

The comparative stabilizing effects of the anticoagulants; Fluoride oxalate, EDTA and Heparin on fasting blood glucose level were determined, using the spectrophotometry (glucose oxidase) method. Fasting blood samples were taken from ten (10) diabetic patients and ten (10) non-diabetic people, and the blood glucose levels determined at 30 min intervals for a maximum time of 2 h. Our results showed that the rate at which plasma glucose changes with time varies with specific anticoagulants. With Fluoride oxalate and Heparin, it increased by 1.77 and 6.67%, respectively, while with EDTA it decreased by 4.0%, within the first 30 minutes for non-diabetics. For diabetics, within the same period, with Fluoride oxalate and Heparin it increased by 1.9 and 3.7%, respectively, while with EDTA it decreased by 3.6%. Blood glucose levels were however shown to increase significantly (p<0.05) at 60 min (1 h) with the three anticoagulants in diabetics and non-diabetics. But at 120 min (2 h) plasma glucose in Fluoride oxalate, EDTA and Heparin decreased by 16.4, 17.5 and 8.5%, respectively for non-diabetics and by 10.6, 9.8 and 8.6%, respectively for diabetics. These showed that Fluoride oxalate had a better stabilizing effect on plasma glucose within the first 30 minutes while Heparin is a better stabilizer at after 120 min.
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  Cite this Reference:
Nwangwu C.O. Spencer, Josiah J. Sunday, Omage K. Erifeta, O. Georgina, Asuk A. Agbor, Uhunmwangho S. Esosa and O. Jenevieve, 2011. Comparative Stabilizing Effects of Some Anticoagulants on Fasting Blood Glucose of Diabetics and Non-diabetics, Determined by Spectrophotometry (Glucose Oxidase).  Asian Journal of Medical Sciences, 3(6): 234-236.
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