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    Abstract
2011 (Vol. 3, Issue: 6)
Article Information:

Change in Organs Weight and Antioxidant Potential of Combined Effects of Aqueous Extracts of Phyllanthus amarus and Vitex doniana Stem Bark on Streptozotocin-Induced Dibetic Rats

D.B. James, O.A. Owolabi, A.O. Oluloto, H. Mohammed and O.A. Muhammed
Corresponding Author:  D.B. James 

Key words:  Antioxidant, aqueous extracts, albio rats, catalase, diabetes, Phyllatus amarus, polytherapy, superoxide dismutase, Vitex doniana
Vol. 3 , (6): 237-242
Submitted Accepted Published
2011 September, 23 2011 November, 04 2011 December, 25
Abstract:

Phyllanthus amarus and Vitex doniana are used folklore plants in several disorders due to their excellent properties and potent phyto-constituents. In this study, change in organs weight and antioxidant potential of combined effects of aqueous extracts of Phyllanthus amarus and Vitex doniana stem bark on streptozotocin - induced diabetic rats was investigated. In a 21 days study, animals were divided into six groups (A- F) of six rats each. Group A served as normal control, group B as diabetic control, Groups C, D and E were administered with three different plant extracts (100 mg/kg of Phyllanthus amarus, Vitex doniana and combination of the two plants repectively, group F was treated with standard drug insulin (5 units/kg). Administration of Vitex doniana extracts and Phyllanthus amarus and their combination significantly (p<0.05) decrease fasting blood glucose. Significant (p<0.05) increase in weight gain for animals in treated groups when compared with diabetic group was observed. Treated groups significantly (p<0.05) decrease levels of thiobarbituric acid (TBARS), while catalase and Superoxide Dismutase (SOD) in liver and kidney were significantly (p<0.05) increase when compared with diabetic control group. Phyllanthus amarus treated groups shows significantly (p<0.05) higher SOD in the liver and kidney when compared with standard drug. While kidney catalase was significantly (p<0.05) higher in the groups treated by Vitex doniana and Phyllanthus amarus compared with other treated group. These results suggest that the use of aqueous extract of these plants and their combination possess antidiabetic and antioxidant activity, which could exert a beneficial action against the disease associated with free-radicals complications.
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  Cite this Reference:
D.B. James, O.A. Owolabi, A.O. Oluloto, H. Mohammed and O.A. Muhammed, 2011. Change in Organs Weight and Antioxidant Potential of Combined Effects of Aqueous Extracts of Phyllanthus amarus and Vitex doniana Stem Bark on Streptozotocin-Induced Dibetic Rats.  Asian Journal of Medical Sciences, 3(6): 237-242.
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