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Abstract
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Article Information:
Estimation of Reference Values for Liver Function Tests for Adult Population in North-Rift Valley, Kenya
Alice Juma, Eliud N.M. Njagi and Joseph J.N. Ngeranwa
Corresponding Author: Eliud N.M. Njagi
Submitted: 2011 October, 26
Accepted: 2011 November, 18
Published: 2011 December, 25 |
Abstract:
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The aim of this study was to determine age and sex based reference ranges for eight liver function
biochemical parameters for the adult population of North Rift Valley region. This was a population based crosssectional
study carried out at Moi Teaching and Referral Hospital in collaboration with the Regional Blood
Transfusion Center, North Rift. A total of 400 volunteer blood donors were screened and 367 (211 males and
156 females) free from human immunodeficiency virus, hepatitis B and C virus, and syphilis were used in the
analysis. Cobas Integra® 400 plus was used to analyze the eight liver function clinical chemistry parameters.
Reference ranges were constructed using nonparametric methods to estimate 2.5 and 97.5 percentiles of
distribution as lower and upper reference limits, respectively. Significant age specific differences in the North
Rift Valley Kenyan reference ranges were observed for alkaline phosphatase, alanine aminotransferase, gamma
glutamyltransferase while significant sex related differences were also observed for total protein, albumin,
alkaline phosphatase, alanine and aspartate aminotransferase, gamma glutamyltransferase, total and direct
bilirubin. The developed North Rift Valley Kenyan liver function clinical chemistry reference ranges differ
from the American values commonly used in Kenyan Hospitals. This study provides adult sex and age specific
liver function reference range values to be used in North Rift Valley region. This study recommends adoption
of these reference ranges in North Rift valley and determination of similar values for other regions in Kenya.
Key words: Age, adult reference ranges, liver function parameters, sex, , ,
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Cite this Reference:
Alice Juma, Eliud N.M. Njagi and Joseph J.N. Ngeranwa, . Estimation of Reference Values for Liver Function Tests for Adult Population in North-Rift Valley, Kenya. Asian Journal of Medical Sciences, (6): 243-249.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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