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2011 (Vol. 3, Issue: 6)
Article Information:

Ameliorative Effects of Ethanolic Neem Extract on Dietary Aflatoxin-Induced Hematological Damage and Hepatotoxicity in Mice

C.P. Anokwuru, C.N. Ezekiel, O.A. Alabi, P.D. Shallie and M.T. Haruna
Corresponding Author:  C.P. Anokwuru 

Key words:  Aflatoxin, Azadirachta indica, bloob, hepatotoxicity, neem, ,
Vol. 3 , (6): 254-260
Submitted Accepted Published
2011 September, 08 2011 November, 04 2011 December, 25
Abstract:

The aqueous ethanolic extract of Azadirachta indicia bark was evaluated for its ability to ameliorate aflatoxin induced damage to blood cells and hepatotoxicity in albino mice. Six groups (I-VI) of mice were used in this study. Mice in group I were exposed to aflatoxin-free feed only while those in group II were fed with aflatoxin contaminated feed only for 3 weeks. Groups III-V were exposed to aflatoxin contaminated feed for three weeks each and then treated interperitonially with 0.25 mL of 50, 100 and 150 mg/kgbwt aqueous ethanolic extract of A. indica, respectively, at one dose daily for 7 days. Group VI was fed aflatoxin-free feed for three weeks and then administered with 150 mg/kgbwt A. indica extract to ascertain the effect of this concentration of the extract on the mice. Aflatoxin was immunosuppressive, leading to a reduction in PCV, WBC, neutrophile and lymphocyte counts in group II mice as compared to other groups. Mice in group II had the highest significantly different (p<0.05) mean lesion score as compared to the control group. However with an increase in extract concentration a strong capacity to boost hematological parameters was recorded for the extract at the expense of compromising hepatocytes integrity. This study showed that low concentration of aqueous ethanolic extract of A. indica bark is safe and therapeutic for ameliorating hematological damage and hepatotoxicity induced by diatary aflatoxin.
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  Cite this Reference:
C.P. Anokwuru, C.N. Ezekiel, O.A. Alabi, P.D. Shallie and M.T. Haruna, 2011. Ameliorative Effects of Ethanolic Neem Extract on Dietary Aflatoxin-Induced Hematological Damage and Hepatotoxicity in Mice.  Asian Journal of Medical Sciences, 3(6): 254-260.
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