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    Abstract
2009 (Vol. 1, Issue: 3)
Article Information:

Anti-inflammatory and Anti-nociceptive Activity of Mitragyna parvifolia

Vikas Gupta, Pawan Kumar, Parveen Bansal and Ranjit Singh
Corresponding Author:  Vikas Gupta 

Key words:  em>Mitragyna parvifolia, paw edema method, rubiaceae, tail-flick method, , ,
Vol. 1 , (3): Page No: 97-99
Submitted Accepted Published
2009 August, 22 2009 Sept., 02
Abstract:

The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Mitragyna parvifolia (MPEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum anti-inflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and this effect was equivalent to phenylbutazone (PBZ) (80 mg/kg, orally) (p<0.05). The extract also demonstrated marked antinociceptive activity at a dose of 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg orally) (p<0.05). The results of this study have established the anti-inflammatory activity and antinociceptive activity of leaf extracts of Mitragyna parvifolia.
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  Cite this Reference:
Vikas Gupta, Pawan Kumar, Parveen Bansal and Ranjit Singh, 2009. Anti-inflammatory and Anti-nociceptive Activity of Mitragyna parvifolia.  Asian Journal of Medical Sciences, 1(3): Page No: 97-99.
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