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Abstract
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Article Information:
Anti-inflammatory and Anti-nociceptive Activity of Mitragyna parvifolia
Vikas Gupta, Pawan Kumar, Parveen Bansal and Ranjit Singh
Corresponding Author: Vikas Gupta
Submitted: 2009 August, 22
Accepted: 2009 Sept., 02
Published: |
Abstract:
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The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Mitragyna parvifolia (MPEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum anti-inflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and this effect was equivalent to phenylbutazone (PBZ) (80 mg/kg, orally) (p<0.05). The extract also demonstrated marked antinociceptive activity at a dose of 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg orally) (p<0.05). The results of this study have established the anti-inflammatory activity and antinociceptive activity of leaf extracts of Mitragyna parvifolia.
Key words: em>Mitragyna parvifolia, paw edema method, rubiaceae, tail-flick method, , ,
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Cite this Reference:
Vikas Gupta, Pawan Kumar, Parveen Bansal and Ranjit Singh, . Anti-inflammatory and Anti-nociceptive Activity of Mitragyna parvifolia. Asian Journal of Medical Sciences, (3): Page No: 97-99.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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