Home           Contact us           FAQs           
 
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
    Abstract
2013 (Vol. 5, Issue: 1)
Article Information:

Possible Reversal of Sodium Arsenate-induced Liver Toxicity by Hexane Leaf Extract of Alchornea laxiflora

Uhunmwangho S. Esosa, Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday and Nwangwu C.O. Spencer
Corresponding Author:  Omage Kingsley 

Key words:  Alchornea laxiflora, hexane, liver homogenate, serum enzymes, sodium arsenate, toxicity,
Vol. 5 , (1): 3-8
Submitted Accepted Published
July 24, 2012 August 28, 2012 February 25, 2013
Abstract:

This research was aimed at evaluating the anti-toxicity potentials or properties of A. laxiflora Thus, the possible reversing effect of sodium arsenate-induced liver toxicity by hexane leaf extract of Alchornea laxiflora was investigated using adult wistar albino rats weighing between 150-200 g as experimental model. Oral administration of the extract at varying doses (0.5, 1.0, 5.0 and 10.0 mg/kg body weight) was shown to significantly (p<0.05) decrease the effect of sodium arsenate-induced liver damage by reducing the activities of AST, ALT, ALP, GGT and TB, both in the serum and liver homogenate. Pre-treatment with the extract prior to the intra-peritoneal administration of the toxicant (sodium arsenate) at a dose of 2 mg/kg body weight was shown to be more effective at reversing the effect of the toxicant than post-treatment with the extract after intoxication. Thus, the ability of Alchornea laxiflora leaf extract to protect against sodium arsenate induced liver damage by possible reversal of arsenic toxicity suggests that this plant extract might be suitable for the treatment of sodium arsenate toxicity.
Abstract PDF HTML
  Cite this Reference:
Uhunmwangho S. Esosa, Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday and Nwangwu C.O. Spencer , 2013. Possible Reversal of Sodium Arsenate-induced Liver Toxicity by Hexane Leaf Extract of Alchornea laxiflora.  Asian Journal of Medical Sciences, 5(1): 3-8.
    Advertise with us
 
ISSN (Online):  2040-8773
ISSN (Print):   2040-8765
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved