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Abstract
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Article Information:
Stepwise Deterioration of Prothrombin, Factors I, IV but Not Factor XIII in Progressive Stages of Liver Cirrhosis and HCC
Mohamed Hessien, Mohamed Ayad, Wafaa M. Ibrahim and Batoul Izzul Arab
Corresponding Author: Mohamed Hessien
Submitted: 2009 June, 22
Accepted: 2009 December, 18
Published: 2010 January, 20 |
Abstract:
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This study was designated to investigate the haemostatic changes during the gradual progression of
liver diseases. The study included forty patients; thirty of them had liver cirrhosis with different stages
(classified according to Childs-Pugh classification) and 10 with hepatocellular carcinoma (HCC). Haemostatic
variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet
count were estimated and compared with the baseline levels of healthy subjects (n=10). The results obtained
demonstrated that fibrinogen level progressively decreased and PT prolonged progressively in Child A, C hild
B, Child C and reached the maxima in HCC patients. Calcium significantly increased in mild (Child A) and
moderate (Child B) but not in Child C cirrhosis and HCC patients, whereas FXIII level did not show any
change. Some haemostatic variables were correlated with the hepatic markers albumin and bilirubin but not
with aminotransferases. The results of this study indicated that the haemostatic abnormalities in fibrinogen,
calcium and PT (but not FXIII) go in parallel to the gradual dysfunction of liver.
Key words: Child-Pugh classification, coagulation factors, fibrinogen, FIV, FXIII, HCC, liver cirrhosis and PT
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Abstract
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Cite this Reference:
Mohamed Hessien, Mohamed Ayad, Wafaa M. Ibrahim and Batoul Izzul Arab, . Stepwise Deterioration of Prothrombin, Factors I, IV but Not Factor XIII in Progressive Stages of Liver Cirrhosis and HCC. Asian Journal of Medical Sciences, (1): Page No: 1-6.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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