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Abstract
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Article Information:
Some Biochemical Effect of Intraperitoneal Administration of Phyllanthus amarus Aquoeus Extacts on Normaglycemic Albino Rats
D.B. James, N. Elebo, A.M. Sanusi and L. Odoemene
Corresponding Author: Dorcas B James
Submitted: 2009 June, 23
Accepted: 2009 December, 16
Published: 2010 January, 20 |
Abstract:
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The effect of aqueous extract of the w hole plant of Phyllanthus amarus was assessed for some
biochemical effect in albino rats. Different doses (50, 100 and 200mg/kg bodyweight) of crude extract was
administered Intraperitoneal for 14 consecutive days. Glucose tolerance test shows that there was significant
(p < 0.05) reduction in the serum blood glucose from 30minites up to 120minites for animals treated with 50mg
and 200mg body weight while from 120minites up to 180minites there was no significant (p>0.05) change for
all the treated animals. The level of serum aspartate amino transfarase (AST) and alanine amino transfarase
(ALT) of animals treated with 50mg and 100mg kg body weight was significantly (p < 0.05) lower when
compared with that of the control. Creatinine concentration was significantly (p<0.05) lower at 200mg body
weight while no significant (p>0.05) change observed in urea concentration for the treated animals. There was
no significant (p>0.05) change in packed cell volume (PCV) and heamoglobin (Hb) observed for all the treated
animals compared with control. Significant (p>0.05) reduction in the cholesterol concentration for the animals
treated with 50mg and 200mg compared with the control was observed. There was no significant (p>0.05)
difference in the triglyceride concentration for the animals treated with 50mg and 100mg kg body weight. The
low density cholesterol was significantly (p<0.05) low er for all the treated animals (100mg and200mg), while
there were no significant (p >0.05) change in the level of high density cholesterol for animals treated 100mg
and 200mg body weight of the extract.
Key words: Aqueous extract, glucose tolerance, intraperitoneal, lipid profiles, Phyllanthus amarus, transaminases,
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Cite this Reference:
D.B. James, N. Elebo, A.M. Sanusi and L. Odoemene, . Some Biochemical Effect of Intraperitoneal Administration of Phyllanthus amarus Aquoeus Extacts on Normaglycemic Albino Rats . Asian Journal of Medical Sciences, (1): Page No: 7-10.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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