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Abstract
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Article Information:
Streptozotocin-induced Hyperglycemia Produces Dark Neuron in CA3 Region of Hippocampus in Rats
S.H. Ahmadpour, Y. Sadeghi and H. Haghir
Corresponding Author: Shahriar Ahmadpour
Submitted: 2009 September, 29
Accepted: 2009 November, 23
Published: 2010 January, 20 |
Abstract:
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Dark neurons have been reported in many pathological conditions, such as epilepsy, ischemia and
hypoglycemia. All these pathological conditions cause increased extracellular excitatory neurotransm itters like
glutamate. Glutamate has been involved in dark neuron formation. Increased extracellular glutamate has been
reported in hippocampus of diabetic state. We aimed to study the effect of streptozotocin-induced diabetes on
dark neuron formation in CA3 region of diabetic rats. Diabetes was induced by a single intrape ritoneal (IP)
injection of streptozotocin (STZ) at a dose of 60 mg/kg dissolved in saline. C ontrol Animals w ere injected w ith
saline only. In the end of 8 weeks, the brains were removed and hippocampi studied by gallyas method and
transmission electron microscopy. Dark neurons in CA3 region of STZ -induced diabetic group showed high
darkly Stained somata and axons. Dark neurons also showed shrinkage and detachment from surrounding
tissues. Ultastructurally injured neurons in CA3 region of diabetic rats showed dark and electron dense
appearance, chromatin condensation, margination and clumping. Present results showed that STZ-induced
diabetes produces dark neuron in CA3 pyramidal layer of diabetic rats after 8 weeks. The mode of death in dark
neurons is apoptosis.
Key words: CA3, dark neuron, diabetes, rat, stereptozotocin, ,
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Abstract
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Cite this Reference:
S.H. Ahmadpour, Y. Sadeghi and H. Haghir, . Streptozotocin-induced Hyperglycemia Produces Dark Neuron in CA3 Region of Hippocampus in Rats. Asian Journal of Medical Sciences, (1): Page No: 11-15.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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