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2013 (Vol. 5, Issue: 4)
Article Information:

Assessment of Some Selected Trace Metals in Chronic Myeloid Leukemia Patients in a Tertiary Health Facility in South West Nigeria

E.O. Akanni, A.J. Onuegbu, T.O. Adebayo, B.A. Eegunranti and T.Oduola
Corresponding Author:  Dr. Akanni E. Olufemi 

Key words:  Chronic myeloid leukemia, hematological parameters, trace metals, , , ,
Vol. 5 , (4): 71-75
Submitted Accepted Published
February 02, 2012 February 22, 2012 August 25, 2012
Abstract:

Some selected trace metals; Iron (Fe), Copper (Cu), Manganese (Mn), Chromium (Cr), Selenium (Se), Calcium (Ca), Zinc (Zn) and Magnesium (Mg) in Chronic Myeloid Leukemia (CML) patients were assessed. Seventy five (75) leukemic patients and 50 apparently healthy control subjects were evaluated in this study. Hematological parameters were estimated by automation SYSMEX KX-21N and the trace elements analysed using Atomic Absorption Spectrophotometry. There were statistical significant differences between serum Fe, Cu, Mn, Se, Ca, Zn and Mg of leukemic patients and that of their respective control subjects (p<0.05) while there was no significant difference between serum chromium of leukemic patients and the control subjects (p>0.05). Variation also existed between the patients and control values in the hematological parameters such as: PCV, MCV, MCHC, WBC, platelet etc. The study reveals that serum trace elements are useful indices of the extent of the disease in leukemia patients, their levels are independent of a non specific acute-phase reaction and restoration of serum trace elements are useful in assessing response to treatment in leukemia patients. Monitoring of the respective trace elements in the CML patients could therefore be an essential part of managing the patients.
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  Cite this Reference:
E.O. Akanni, A.J. Onuegbu, T.O. Adebayo, B.A. Eegunranti and T.Oduola , 2013. Assessment of Some Selected Trace Metals in Chronic Myeloid Leukemia Patients in a Tertiary Health Facility in South West Nigeria.  Asian Journal of Medical Sciences, 5(4): 71-75.
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ISSN (Online):  2040-8773
ISSN (Print):   2040-8765
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