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2010 (Vol. 2, Issue: 3)
Article Information:

Glomerular Filtration Rate Assessment Using Creatinine Related Parameters for Healthy Adult Kenyan Population

Stanley K. Waithaka, Eliud N. Njagi, Joseph N. Ngeranwa, Bernard M. Chiuri, Leonard J. Njagi, Wilfred K. Gatua and Daniel M. Mwangi
Corresponding Author:  Stanley Kinge Waithaka 

Key words:  Adult kenyan, glomerular filtration rate, kenyatta national hospital, reference range, , , reference range, glomerular filtration rate, adult
Vol. 2 , (3): Page No: 141-145
Submitted Accepted Published
2010 April, 22 2010 May, 14 2010 June, 25
Abstract:

The purpose of the study was to establish the reference ranges of measured creatinine clearance and estimated creatinine clearance for adult Kenyan population. A prospective study carried out in clinical chemistry laboratory of Kenyatta National Hospital involving 265 healthy individuals between 18-60 years. Reference ranges were constructed by using the parametric methods to estimate 2.5 and 97.5 percentiles of distribution as lower and upper reference limits. The glomerular filtration rate assessment of the adult healthy Kenyan population was carried out by investigating Serum Creatinine (SrCr), 24 h urine creatinine clearance (Mcrcl), estimated creatinine clearance (Ecrcl), Urine Creatinine (UCr) and Urine Volume (UV). Two hundred and sixty five voluntarily study subjects comprising of 106 male and 159 females were recruited in the study. Sex related reference values were established as follows: SrCr [male:68-128), female: 60-122] umol/l, Mcrcl [male:52-110), female: 50-92] ml/min, Ecrcl [male:54-118), female: 58-106] ml/min, UCr [male:3588-10,400, female:3262-9886] umol/l and UV [male:875-2301, female: 802-2092] ml/24 h. Same sex mean difference was found for the established reference ranges of M crcl and Ecrcl (male p = 0.021 and female p = 0.000). Decline rate in creatinine clearance in the ages under investigation were: male measured creatinine clearance (0.46 ml/min/year), male estimated creatinine clearance (0.29 ml/min), female measured creatinine clearance (0.39 m/min/year) and female estimated creatinine clearance (0.2 ml/min). In conclusion, sex specific reference ranges for the assessment of glomerular filtration rate has been established. Age is an important factor in the interpretation of creatinine clearance of an individual. These reference ranges are different from those reported in literature, therefore each clinical chemistry laboratory should establish its own.
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  Cite this Reference:
Stanley K. Waithaka, Eliud N. Njagi, Joseph N. Ngeranwa, Bernard M. Chiuri, Leonard J. Njagi, Wilfred K. Gatua and Daniel M. Mwangi, 2010. Glomerular Filtration Rate Assessment Using Creatinine Related Parameters for Healthy Adult Kenyan Population.  Asian Journal of Medical Sciences, 2(3): Page No: 141-145.
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ISSN (Online):  2040-8773
ISSN (Print):   2040-8765
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