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Article Information:
A Study of the Anti-Inflammator Y and Analgesic Activities of Aqueous Extract of Nauclea latifolia Leaves in Rodents
A.D.T. Goji, A. Mohammed, Y. Tanko, I. Ezekiel, A.O. Okpanchi and A.U.U. Dikko
Corresponding Author: A.D.T. Goji
Submitted: 2009 December, 07
Accepted: 2009 December, 27
Published: 2010 December, 24 |
Abstract:
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This study investigates the anti- inflammatory and analgesic activity of the leaves extract of Nauclea
latifolia in formalin induced oedema and acetic acid induced writhing in Rodents.The aqueous extract of the
leaves of Nauclea latifolia of the family of Rubiaceae w as evaluated for its analgesic and anti-inflammatory
activities. The extract exhibited significant p<0.05 and dose dependent analgesic activities between 50,100 and
150 mg/kg body weight i.p. in acetic acid induced writhing and anti-inflammatory effects between 50 and 100
mg/kg body weight i.p. in formalin induced oedema in rats. The activities of the extract were comparable to
that of the reference non- steroidal analgesic and anti-inflammatory drug: piroxicam. LD50 value was calculated
to be 226.3 mg/kg body weight intraperitoneally. The extract revealed the presence of chemical constituents
such as flavonoid, tannins alkaloid and saponins when phytochemically investigated. The results obtained from
the present studies supported the claims of the use of the plant in the management of dysentery and pain in the
throat in human.
Key words: Acetic acid, analgesic, anti-inflamm ation, formalin, Nauclea latifolia, piroxicam,
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Cite this Reference:
A.D.T. Goji, A. Mohammed, Y. Tanko, I. Ezekiel, A.O. Okpanchi and A.U.U. Dikko, . A Study of the Anti-Inflammator Y and Analgesic Activities of Aqueous Extract of Nauclea latifolia Leaves in Rodents. Asian Journal of Medical Sciences, (6): 244-247.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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