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Abstract
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Article Information:
Evaluation Analgesic, Anti-Inflammatory and Antiepileptic Effect of Hydro Alcoholic Peel Extract of Punica granatum (pomegranate)
S. Olapour and H. Najafzadeh
Corresponding Author: Hossein Najafzadeh
Submitted: 2010 December, 06
Accepted: 2010 December, 22
Published: 2010 December, 24 |
Abstract:
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Punica granatum L. is a w idely used plant that has high nutritional value. The aim of present study
was evaluation analgesic, anti-inflammatory and antiepileptic effect of Pomegranate Peel Extract (PPE) in mice.
Hydro alcoholic peel extract of pomegranate was prepared by maceration method. In the first study the number
of writhing was counted within 10 min in one group of mice after 10 min later to acetic acid injection
intraperitoneally. In other group, the extract was intraperitoneally administrated at dose 400 mg/kg by 20 min
before acetic acid injection and the number of writhing was counted as later group. In formalin test; the
formalin was subcutaneously injected in foot of mice. The licking time of foot was calculated 5 and 15-25 min
after formalin injection. In other group, test was done as previous but the extract was intraperitoneally
administrated 400 mg/kg by 20 min before formalin injection. In the second study; the mice were divided in
to 6 groups. One group of mice received strychnine at dose 3 mg/kg as negative control. Other group received
Phenobarbital before strychnine administration as a positive control. In 4 groups of mice, the PPE was
administrated at 100, 200, 400 and 600 mg/kg before strychnine administration. The onset, duration and number
of convulsion were measured and time of death was determined in 30 min after strychnine administration. The
results of first study showed that pomegranate peel extract was considerably decreased licking and writhing.
The results of second study showed the PPE had significantly anticonvulsive effect. Thus, PPE has analgesic,
anti-inflammatory and antiepileptic effect.
Key words: Analgesia, anti-inflammation, antiepilepsy, mice, pomegranate peel extract, ,
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Abstract
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Cite this Reference:
S. Olapour and H. Najafzadeh, . Evaluation Analgesic, Anti-Inflammatory and Antiepileptic Effect of Hydro Alcoholic Peel Extract of Punica granatum (pomegranate). Asian Journal of Medical Sciences, (6): 266-270.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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