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2012 (Vol. 3, Issue: 2)
Article Information:

Effects of Garcinia kola on the Lipid Profile of Alloxan-Induced Diabetic Wistar Rats

E.K. Nwangwa
Corresponding Author:  E.K. Nwangwa 

Key words:  Diabetes mellitus, Garcinia kola, lipid profile, , , ,
Vol. 3 , (2): 39-42
Submitted Accepted Published
September 27, 2011 November 15, 2011 April 25, 2012
Abstract:

In this study, the effects of Garcinia kola on the lipid profile of alloxan-induced diabetic Wistar rats were studied. A total of twenty four (24) albino rats of wistar strain weighing between 100-150 g were made diabetic by single freshly prepared intraperitoneal injection of 150 mg/dL of alloxan monohydrate. Eight (8) weeks after confirmation of diabetes, the rats were randomly divided into four (4) experimental groups (n = 6). Group I (Control) rats were treated with 1ml of 5% ethanol, Group II ( diabetic rats received 1ml of 5% ethanol), Group III (Diabetic rats treated with 400 mg/kg of extract of Garcinia kola and 1mL of 5% ethanol) and Group IV, (Diabetic rats received 400 mg/kg of extract of Garcinia kola, 1 mL of 5% ethanol and 1 mL of honey).The extracts were administered twice daily for four (4) weeks. The blood glucose level and Lipid profile was analysed. The results shows that Garcinia kola has a significant (p<0.05) hypoglycaemic effect on diabetic rats and significantly (p<0.05) decreased the level of Total Cholesterol (TC), Low Density Lipoprotein (LDL) and Triglyceride (TG) and significantly (p<0.05) increase in the level of High density lipoprotein compared with the diabetic non-treated group. These findings if applied can be of help in the management of diabetic patients.
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  Cite this Reference:
E.K. Nwangwa, 2012. Effects of Garcinia kola on the Lipid Profile of Alloxan-Induced Diabetic Wistar Rats.  British Journal of Pharmacology and Toxicology, 3(2): 39-42.
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