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Abstract
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Article Information:
Effects of Essential Oil Extracted from the Leaves of Hoslundia opposita Hoslundia opposita Biochemical Indices in Rats
J.O. Akolade, N.O. Muhammad, L.A. Usman, M.B. Odebisi, A.O. Sulyman and F.T. Akanji
Corresponding Author: J.O. Akolade
Submitted: November 16, 2013
Accepted: November 25, 2013
Published: June 20, 2014 |
Abstract:
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Biochemical effect of essential oil extracted from the leaves of Hoslundia opposita on selected toxicological indices was evaluated. Twenty four Rattus norvegicus were randomly selected into four groups. The rats were treated with 110 and 220 mg/kg body weight (b.wt.) of the essential oil. All treatments were administered intraperitoneally, once a day for four days. The Alkaline phosphatase (ALP), alanine (ALT) and aspartate transaminases (AST) activities in the liver as well as kidney ALP and AST of the rats treated with the 110 and 220 mg/kg b. wt. of oil were significantly (p<0.05) lower, while the serum ALP and AST activities were higher compared to values in the non-treated rats. More so, the heart AST activities of rats treated with 220 mg/kg b. wt. of the oil were significantly (p<0.05) lower. However, serum protein, albumin, urea, total, conjugated bilirubin, ALT/AST and organ-body weight ratios were not significantly (p>0.05) altered, whereas serum creatinine concentrations were significantly (p<0.05) lower compared to those of non-treated control. Biochemical alterations observed in this study showed that the oil may not be completely safe when administered.
Key words: Enzymes, essential oil, Hoslundia opposita, rats, toxicity, ,
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Cite this Reference:
J.O. Akolade, N.O. Muhammad, L.A. Usman, M.B. Odebisi, A.O. Sulyman and F.T. Akanji, . Effects of Essential Oil Extracted from the Leaves of Hoslundia opposita Hoslundia opposita Biochemical Indices in Rats. British Journal of Pharmacology and Toxicology, (3): 109-114.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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