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     British Journal of Pharmacology and Toxicology

    Abstract
2015(Vol.6, Issue:3)
Article Information:

Beneficial Effects of Hesperidin against Cisplatin-Induced Nephrotoxicity and Oxidative Stress in Rats

Wafaa R. Mohamed, El-Shaimaa A. Arafa, Basim A. Shehata, Gamal A. El Sherbiny and Abdel Nasser A.M. Elgendy
Corresponding Author:  Wafaa R. Mohamed 
Submitted: November ‎30, ‎2014
Accepted: February ‎8, ‎2015
Published: July 20, 2015
Abstract:
Cisplatin has been frequently used for treatment of wide variety of tumors. The use of cisplatin is associated with severe cytotoxicity such as nephrotoxicity, hepatotoxicity and spermiotoxicity which radically limits its clinical use. The present study aimed to investigate the possible protective effects of multiple doses of hesperidin against cisplatin-induced nephrotoxicity induced by single i.p injection of cisplatin (7.5 mg/kg). Hesperidin was given to rats at two different doses (100 and 200 mg/kg p.o) for 7 days starting one day before cisplatin injection. Blood samples were collected for determination of serum creatinine and Blood Urea Nitrogen (BUN) levels. Kidneys were used for the determination of Malondialdehyde (MDA), Glutathione (GSH) and total nitrate and nitrite contents. Liver samples were also used for histopathological examination. Results showed that hesperidin significantly reduced cisplatin-induced elevations in serum creatinine and BUN levels. It also significantly reduced kidney MDA and NO content and elevated GSH content. In conclusion, hesperidin greatly protected kidney against cisplatin-induced toxicity in a dose-dependent manner.

Key words:  Blood urea nitrogen, cisplatin, creatinine, hesperidin, nephrotoxicity, oxidative stress,
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Cite this Reference:
Wafaa R. Mohamed, El-Shaimaa A. Arafa, Basim A. Shehata, Gamal A. El Sherbiny and Abdel Nasser A.M. Elgendy, . Beneficial Effects of Hesperidin against Cisplatin-Induced Nephrotoxicity and Oxidative Stress in Rats. British Journal of Pharmacology and Toxicology, (3): 56-63.
ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
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