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Abstract
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Article Information:
Hepatoprotective Effect of Aqueous Acetone Extract of Sida alba L. (Malvaceae) Against Alcohol Induced Liver Damage in albinos Wistar Rats
K. Konaté, A. Souza, R.R.R. Aworet Samseny, B. Batchelili, B. Marlaine, M. Lamidi, N. Barro, J. Millogo-Rasolodimby and O.G. Nacoulma
Corresponding Author: Konaté Kiessoun
Submitted: 2010 December, 15
Accepted: 2011 January, 22
Published: 2011 February, 10 |
Abstract:
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The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract
of Sida alba. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally hepatics affections in
albinos Wistar rats. Animals were treated by gavage during 28 days with different doses of aqueous acetone
extracts of Sida alba. (75, 100, 150 mg/kg) suspended in 35% ethanol. Control groups received alcohol 35%
and water. In vivo administration of 35% ethano l for 28 days results an activity of liver marker enzymes (AST,
ALT, ALP), glucose, triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum as compared
with rats which received water (control water). However, administrations of 35% ethanol along with aqueous
acetone extract decreased the activities of liver markers enzyme in serum comparatively to the control water
group (p<0.05 or p<0.01). We noticed that extract at a dose of 150 mg/kg was highly effective than 75 and 100
mg/kg body weight compared to the control water group (ALT and ALP; p>0.05 and p<0.05). This study
revealed that Sida alba presents a hepatoprotective potential and this plant could be traditionally exploited in
the treatment of affection hepatics.
Key words: Albinos Wistar rats, biochemical parameters, hepatoprotective potential, Sida alba , , ,
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Cite this Reference:
K. Konaté, A. Souza, R.R.R. Aworet Samseny, B. Batchelili, B. Marlaine, M. Lamidi, N. Barro, J. Millogo-Rasolodimby and O.G. Nacoulma, . Hepatoprotective Effect of Aqueous Acetone Extract of Sida alba L. (Malvaceae) Against Alcohol Induced Liver Damage in albinos Wistar Rats. British Journal of Pharmacology and Toxicology, (1): 37-42.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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