Home           Contact us           FAQs           
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
2011 (Vol. 3, Issue: 5)
Article Information:

Effects of Oral Administration of Aluminium Chloride on the Histology of the Hippocampus of Wistar Rats

A.A. Buraimoh, S.A. Ojo, J.O. Hambolu and S.S. Adebisi
Corresponding Author:  A.A. Buraimoh 

Key words:  Aluminium chloride, effects, hippocampus, oral administration, wistar rats, ,
Vol. 3 , (5): 509-515
Submitted Accepted Published
2011 July, 17 2011 August, 30 2011 September, 10

The study of the effects of oral administration of aluminium chloride on the Hippocampus of wistar rats was designed in order to ascertain whether the small daily amount of aluminium that gain access to the body produce any damage to the hippocampus. This investigation was carried out using 50 female adult wistar rats.The animals were divided into five groups; 10 rats per group (cage). Stock solution of aluminium chloride was prepared (2 g/L or 2 mg/mL). Different concentrations of aluminium were administered to different groups orally. Group I was control, while Groups II-V were given 0.4, 1, 2, and 3 mg, respectively per each rat with an average weight of between 150-200 g for duration of twelve (12) weeks. The animals were humanly sacrificed using chloroform and then the brain tissues were fixed immediately in Bouinís fluid. The brain sections (hippocampus) were processed through the routine tissue processor. The stained samples were examined by means of light microscope for histological changes. Histological examinations showed clumpy of cell neurons, or reduced pyramidal cells and scant,y neurofibrillary tangle which was an indication of neurodegeneration in the treated groups when compared to the control. It was however, concluded that the oral administration of aluminium chloride could induce brain damage which may impair memory and learning as seen in Alzheimer disease.
Abstract PDF HTML
  Cite this Reference:
A.A. Buraimoh, S.A. Ojo, J.O. Hambolu and S.S. Adebisi, 2011. Effects of Oral Administration of Aluminium Chloride on the Histology of the Hippocampus of Wistar Rats.  Current Research Journal of Biological Sciences, 3(5): 509-515.
    Advertise with us
ISSN (Online):  2041-0778
ISSN (Print):   2041-076X
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved