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2011 (Vol. 3, Issue: 6)
Article Information:

The Protective Effect of Ethanolic Extract of Unripe Pulp of Carica papaya (Pawpaw) Against Potassium Bromate Induced Tissue Damage in Wistar Rats

S.J. Josiah, S.C.O. Nwangwu, A.A. Akintola, T. Allu, U. Usunobun, Njoya Helen and B.I. Adejumo
Corresponding Author:  JOSIAH, SUNDAY JOEL 

Key words:  Carica papaya, malondialdehyde, potassium bromate, tissue damage, , ,
Vol. 3 , (6): 597-600
Submitted Accepted Published
2011 Month, 00 2011 September, 30 2011 November, 15
Abstract:

The protective role of ethanolic extract of unripe pulp of Carica papaya (fruit), against potassiumbromate induced tissue damage in wistar rats was investigated. The animals were grouped into four groups (A, B, C, D) of five rats. Group A was administered 1 mL of 0.25 M sucrose solution. 60 mg/kg of Potassium bromate KBrO3 was administered orally to rats in groups B, C and D. Groups C and D were pretreated with 250 and 500 mg/kg of the extracts for fourteen (14) days, respectively. The organ to body-weight ratio, total amino acid, total protein and malondialdeyde (MDA) concentration in the brain, spleen, kidney, liver, and heart were colorimetrically measured as an assessment of the level of tissue damage. All the parameters studied increases significantly in all the tissues of rats group B. There was significant decrease in the organ-to-body weight ratio and total protein level in all the tissues investigated (p<0.05), when compared with Group B at both doses of the extract. The total protein level of the stomach had a drastic reduction at 500 mg/kg. Also, the Amino acid level of investigated tissues decreased significantly, while malondialdeyde levels decreased significantly in a dose dependent manner. These findings suggest that ethanolic extract of unripe pulp of Carica papaya may be protective against KBrO3 induced tissue damage in Wistar rats.
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  Cite this Reference:
S.J. Josiah, S.C.O. Nwangwu, A.A. Akintola, T. Allu, U. Usunobun, Njoya Helen and B.I. Adejumo, 2011. The Protective Effect of Ethanolic Extract of Unripe Pulp of Carica papaya (Pawpaw) Against Potassium Bromate Induced Tissue Damage in Wistar Rats.  Current Research Journal of Biological Sciences, 3(6): 597-600.
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