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    Abstract
2009 (Vol. 1, Issue: 3)
Article Information:

Behavioural Effects of Hydro-methanolic Crude Extract of Aerial Part of Indigofera pulchra in Mice

Y. Tanko, I. Ezekiel, A.O. Okpanachi, A.D.T. Goji, H. Ndebi, K.Y Musa and A. Mohammed
Corresponding Author:  Tanko,Yusuf 

Key words:  Indigofera pulchra, diazepam, behavioral, motor coordination, , ,
Vol. 1 , (3): Page No: 89-93
Submitted Accepted Published
2009 June, 29 2009 July, 07
Abstract:

Indigofera pulchra is used traditionally as prophylactic against snake-bite, treatment of infected wounds and as anti-inflammatory. In this study, the behavioural effects of hydromethanolic of the aerial part extracts of Indigofera pulchra were investigated in mice. The results revealed that the extract significantly (p< 0.05) prolonged the onset and reduced the duration of sleep at the dose tested (200mg/kg). The extract significantly (p<0.05) increased exploratory activity at the dose tested (400mg/kg). It produced no significantly motor coordination deficits in mice at the doses tested (100,200 and 400mg/kg). The intraperitoneal median lethal dose in mice was 2,154 mg/kg while the preliminary phytochemical screening revealed the presence of tannins, saponins, steroids and flavonoids. This result suggests that hydromethanolic extract of Indigofera pulchra might contains biologically active principles that are stimulative in nature and lend pharmacological credence to the ethnomedical use of the plant.
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  Cite this Reference:
Y. Tanko, I. Ezekiel, A.O. Okpanachi, A.D.T. Goji, H. Ndebi, K.Y Musa and A. Mohammed, 2009. Behavioural Effects of Hydro-methanolic Crude Extract of Aerial Part of Indigofera pulchra in Mice.  Current Research Journal of Biological Sciences, 1(3): Page No: 89-93.
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ISSN (Online):  2041-0778
ISSN (Print):   2041-076X
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