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2012 (Vol. 4, Issue: 2)
Article Information:

Effect of Ethanol Extract of Sesamum indicum Seeds on Lipid Profile in vivo

Noor Ali Ghani, Muayad S. Shawkat and Mahfoodha A. Umran
Corresponding Author:  Muayad S. Shawkat 

Key words:  HDL, HPLC, LDL, Lipid profile, Sesamum indicum, sesame extract,
Vol. 4 , (2): 159-163
Submitted Accepted Published
2011 November, 01 2011 November, 25 2012 March, 10
Abstract:

The present study was conducted to investigate the effect of active compound (sesamin) found in defatted ethanol extract of Sesamum indicum seeds on the serum levels of lipid in mice. The qualitative and quantitative determination of sesamin bioactive compound in defatted ethanol extract using High Performance Liquid Chromatography (HPLC) analysis was carried out and compared with standard sesamin. It was found that the concentration of sesamin was 79.9% of ethanolic extract according to total peak area. The ffect of active compound (sesamin) in defatted ethanol sesame extract was evaluated in mice blood serum (in vivo) after feeding them high and low fat diet for one month. Defatted Sesame extract at concentration 500 mg/kg of body weight (B.W) showed significant reduction (p#0.05) in the level of total cholesterol (62.26 , 56.14) mg/dl, triglycerides (61.54 , 61.12) mg/dl , and low density lipoprotein LDL (29.97 , 23.21) mg/dl and significant increase in the level of high density lipoprotein HDL (19.39 , 20.70) mg/dl in comparison with both high and low fat diet groups which recorded (80.43 , 68.24) mg/dl, (77.50 , 74.16) mg/dl, (16.80 , 19.32) mg/dl, and (48.09 , 34.08) mg/dL, respectively.
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  Cite this Reference:
Noor Ali Ghani, Muayad S. Shawkat and Mahfoodha A. Umran, 2012. Effect of Ethanol Extract of Sesamum indicum Seeds on Lipid Profile in vivo.  Current Research Journal of Biological Sciences, 4(2): 159-163.
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