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2012 (Vol. 4, Issue: 2)
Article Information:

Antidiabetic Potential of the Aqueous Leaf Extract of Cnidoscolus aconitifolius on Streptozotocin (STZ) Induced Diabetes in Wistar Rat Hepatocytes

J.C. Mordi
Corresponding Author:  J.C. Mordi 

Key words:  blood glucose, body weight, Cnidoscolus aconitifolius, lipid profile, streptozotocin (STZ), ,
Vol. 4 , (2): 164-167
Submitted Accepted Published
2011 November, 03 2011 November, 29 2012 March, 10

Cnidoscolus aconitifolius has been reported to exhibit hypoglycaemic property and hence recommended traditionally for the treatment of diabetes mellitus. However, the effect of Cnidoscolus aconitifolius leaf extract on the biochemical complication of Streptozotocin (STZ) induced-diabetes is yet to be scientifically verified. Body weight changes, blood glucose and serum lipids were assessed as indicators of diabetes severity and complication in this present study. 60 mg/kg body weight of STZ was administered to male Wistar rats intraperitoneally once as a single dose. In a dose dependent manner (100 mg/kg and 200 mg/kg), the aqueous leaf extract were administered orally (by intubation) as single daily dose for a routine period of 21 days. Relative to the control, STZ treatment significantly increased (p<0.05) blood glucose from 90.615.9 mg/dL (Control) to 237.7018.7 mg/dL (STZ group alone). Results further indicated that Cnidoscolus aconitifolius treated group significantly (p<0.05) decreased blood glucose level in a dose dependent manner when compared with STZ induced diabetic group. Coupled with the loss in body weight and disturbed lipid homeostasis (serum total-cholesterol, LDL cholesterol, and TAG) in the diabetic group, Cnidoscolus aconitifolius significantly (p<0.05) returned the changes in body weight and lipid profile close to control values. Serum lipids were significantly (p<0.05) decreased except for serum HDL-cholesterol that was increased by the extract when compared with the STZ treated group. The findings obtained from this study suggest that in STZ- induced diabetic rats, aqueous leaf extract of Cnidoscolus aconitifolius may be effective for the treatment of insulin dependent diabetes mellitus.
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  Cite this Reference:
J.C. Mordi, 2012. Antidiabetic Potential of the Aqueous Leaf Extract of Cnidoscolus aconitifolius on Streptozotocin (STZ) Induced Diabetes in Wistar Rat Hepatocytes.  Current Research Journal of Biological Sciences, 4(2): 164-167.
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