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Abstract
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Article Information:
Antidiabetic Potential of the Aqueous Leaf Extract of Cnidoscolus aconitifolius on Streptozotocin (STZ) Induced Diabetes in Wistar Rat Hepatocytes
J.C. Mordi
Corresponding Author: J.C. Mordi
Submitted: 2011 November, 03
Accepted: 2011 November, 29
Published: 2012 March, 10 |
Abstract:
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Cnidoscolus aconitifolius has been reported to exhibit hypoglycaemic property and hence
recommended traditionally for the treatment of diabetes mellitus. However, the effect of Cnidoscolus
aconitifolius leaf extract on the biochemical complication of Streptozotocin (STZ) induced-diabetes is yet to
be scientifically verified. Body weight changes, blood glucose and serum lipids were assessed as indicators of
diabetes severity and complication in this present study. 60 mg/kg body weight of STZ was administered to
male Wistar rats intraperitoneally once as a single dose. In a dose dependent manner (100 mg/kg and 200
mg/kg), the aqueous leaf extract were administered orally (by intubation) as single daily dose for a routine
period of 21 days. Relative to the control, STZ treatment significantly increased (p<0.05) blood glucose from
90.61±5.9 mg/dL (Control) to 237.70±18.7 mg/dL (STZ group alone). Results further indicated that
Cnidoscolus aconitifolius treated group significantly (p<0.05) decreased blood glucose level in a dose
dependent manner when compared with STZ induced diabetic group. Coupled with the loss in body weight
and disturbed lipid homeostasis (serum total-cholesterol, LDL cholesterol, and TAG) in the diabetic group,
Cnidoscolus aconitifolius significantly (p<0.05) returned the changes in body weight and lipid profile close to
control values. Serum lipids were significantly (p<0.05) decreased except for serum HDL-cholesterol that was
increased by the extract when compared with the STZ treated group. The findings obtained from this study
suggest that in STZ- induced diabetic rats, aqueous leaf extract of Cnidoscolus aconitifolius may be effective
for the treatment of insulin dependent diabetes mellitus.
Key words: blood glucose, body weight, Cnidoscolus aconitifolius, lipid profile, streptozotocin (STZ), ,
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Abstract
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Cite this Reference:
J.C. Mordi, . Antidiabetic Potential of the Aqueous Leaf Extract of Cnidoscolus aconitifolius on Streptozotocin (STZ) Induced Diabetes in Wistar Rat Hepatocytes. Current Research Journal of Biological Sciences, (2): 164-167.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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