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    Abstract
2012 (Vol. 4, Issue: 3)
Article Information:

Comparative Effects of Halofantrine Hydrochloride and Artesunate on the Testis of Guinea Pigs

S.M. Okey and K.V. Olorunshola
Corresponding Author:  S.M. Okey 

Key words:  Artesunate, guinea pigs, halofantrine hydrochloride, malaria, sperm concentration, testis,
Vol. 4 , (3): 247-249
Submitted Accepted Published
October 03, 2011 November 02, 2011 April 05, 2012
Abstract:

Halofantrine Hydrochloride and Artesunate are both recent antimalarial drugs from the class of phenanthrene methanol and Artemisinin respectively used in the effective combat of malaria parasite in Africa. The aim of this research was to study the effects of these antimalarial drugs on the testicular weight and sperm concentration of guinea pigs. Fifteen male adult guinea pigs weighing between 230-700 g were divided into three groups of five guinea pigs each. First group, control was given 0.9% normal saline once daily for five days. The second group was given Halofantrine Hydrochloride 7 mg/kg (in three doses) in one day orally. The third group was given Artesunate with starting dose of 1.4 mg/kg twice the first day and a sustenance dose of 0.7 mg/kg twice daily for four days orally. The guinea pigs were all anesthetized the one day after the last dose. There was no significant difference in the testicular weight and sperm concentration between the control and experimental groups (p>0.05). We concluded that Halofantrine Hydrochloride and Artesunate given at normal therapeutic doses, have no adverse effect on sperm concentration and testicular weight, but have the potential to cause oligospermia following prolong use.
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  Cite this Reference:
S.M. Okey and K.V. Olorunshola, 2012. Comparative Effects of Halofantrine Hydrochloride and Artesunate on the Testis of Guinea Pigs.  Current Research Journal of Biological Sciences, 4(3): 247-249.
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ISSN (Online):  2041-0778
ISSN (Print):   2041-076X
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