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Article Information:
Comparative Effects of Halofantrine Hydrochloride and Artesunate on the Testis of Guinea Pigs
S.M. Okey and K.V. Olorunshola
Corresponding Author: S.M. Okey
Submitted: October 03, 2011
Accepted: November 02, 2011
Published: April 05, 2012 |
Abstract:
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Halofantrine Hydrochloride and Artesunate are both recent antimalarial drugs from the class of
phenanthrene methanol and Artemisinin respectively used in the effective combat of malaria parasite in Africa.
The aim of this research was to study the effects of these antimalarial drugs on the testicular weight and sperm
concentration of guinea pigs. Fifteen male adult guinea pigs weighing between 230-700 g were divided into
three groups of five guinea pigs each. First group, control was given 0.9% normal saline once daily for five
days. The second group was given Halofantrine Hydrochloride 7 mg/kg (in three doses) in one day orally. The
third group was given Artesunate with starting dose of 1.4 mg/kg twice the first day and a sustenance dose of
0.7 mg/kg twice daily for four days orally. The guinea pigs were all anesthetized the one day after the last dose.
There was no significant difference in the testicular weight and sperm concentration between the control and
experimental groups (p>0.05). We concluded that Halofantrine Hydrochloride and Artesunate given at normal
therapeutic doses, have no adverse effect on sperm concentration and testicular weight, but have the potential
to cause oligospermia following prolong use.
Key words: Artesunate, guinea pigs, halofantrine hydrochloride, malaria, sperm concentration, testis,
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Cite this Reference:
S.M. Okey and K.V. Olorunshola, . Comparative Effects of Halofantrine Hydrochloride and Artesunate on the Testis of Guinea Pigs. Current Research Journal of Biological Sciences, (3): 247-249.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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