In the present study we aimed to estimate the Oxidative DNA damage in Type 2 diabetic patients in different haptoglobin polymorphism. Type 2 diabetes is associated with imbalance of antioxidant defense mechanism, causes alteration in various biomolecules, including DNA. The oxidative DNA damage and its repair is very crucial in diabetes; the defect in the repair process may lead to cancer among diabetics. Haptoglobin (Hp) is a polymorphic glycoprotein provides antioxidant function against heam- driven oxidative stress and has strong association with diabetes and its complication. We investigated the DNA damage quantification of lymphocytes by AP site (Apurine/Apyrimidine site) counting and that correlated with Hp polymorphism among type 2 diabetics. The Hp1-1 phenotype had the least DNA damage than HP 2-1 & HP 2-2; this indicates that Hp alleles differ in their protective effects against oxidative damage, and HP 1-1 was the most protective.