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2012 (Vol. 4, Issue: 4)
Article Information:

Haematological Changes Following Acute Trypanosoma brucei brucei Infection in Rabbits

O.G.C. Ezebuiro, J.A. Yohanna, A. Abdulya’aq, H.O. Osue, J.N. Abenga, M.A. Yakasai and A. Attahir
Corresponding Author:  Attahir Abubakar  

Key words:  Acute, T. brucei brucei, haematological changes, Trypanosoma, , ,
Vol. 4 , (4): 414-416
Submitted Accepted Published
February 02, 2012 March 01, 2012 July 10, 2012
Abstract:

This study assessed the haematological changes following acute T. brucei brucei infection in 10 rabbits during a period of six weeks post infection. Six rabbits were inoculated intraperitoneally (IP) with 0.5 mL of blood containing about 1x104 trypanosomes and four rabbits served as uninfected control. All infected rabbits developed acute trypanosomiasis with the following clinical signs and symptoms: slight weight loss, intermittent pyrexia, weakness, lethargy, dull and rough coats, pale mucous membranes, enlarged superficial lymph nodes and anaemia. The difference in mean+standard deviation of Packed Cell Volume (PCV), body weight, temperature, Haemoglobin (Hb) Red Blood Cell (RBC) count of infected and control animals were not statistically significant (p>0.05). However, the mean+standard deviation of total White Blood Cell (WBC) count and differential WBC showed significant differences (p<0.05). The mean percentage (%) +standard deviation of neutrophil count were 35.35+10.74 and 55.58+2.46, lymphocyte were 60.52+9.40 and 34.28+4.80. The platelet count varied significantly with 7.44+1.20 and 10.98+0.85. The result from this study showed that T. brucei brucei infection decreases both platelet (Thrombocytopenia) and neutrophil (Neutropenia), while lymphocyte population is increased (lymphocytosis).
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  Cite this Reference:
O.G.C. Ezebuiro, J.A. Yohanna, A. Abdulya’aq, H.O. Osue, J.N. Abenga, M.A. Yakasai and A. Attahir, 2012. Haematological Changes Following Acute Trypanosoma brucei brucei Infection in Rabbits.  Current Research Journal of Biological Sciences, 4(4): 414-416.
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