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Abstract
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Article Information:
Immuno-Biochemical Alterations in Leishmania major Infected Balb/c Mice after Immunization with Killed Leishmania Vaccine and BCG as Adjuvant
Sara Nemati, Seyedeh Parisa Jafary, Hossein Nahrevanian, Mahin Farahmand and Shahrzad Nahrevanian
Corresponding Author: Hossein Nahrevanian
Submitted: August 30, 2012
Accepted: October 02, 2012
Published: November 20, 2012 |
Abstract:
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BCG is an immune modulatory that inducing humoral and cellular immune responses during a number of
infections including cutaneous leishmaniasis. Killed Leishmania Vaccine (KLV) has been applied for its
immunogenicity in hosts. This study was carried out between 2010 and 2011 at the Department of Parasitology,
Pasteur Institute of Iran. In the present study, alterations of Nitric Oxide (NO) levels, total content of essential trace
elements (Cu, Zn) and liver enzymes (SGOT, SGPT) were investigated in Balb/c mice infected with Leishmania
major. Results showed that BCG induced NO in liver; Zn increased in KLV/BCG and KLV test groups and Cu
decreased in KLV test group, but increased in BCG test group. Moreover to decreasing SGOT level in KLV/BCG
test group, SGPT decreased in BCG test group. Our findings showed that serum trace element concentrations were
altered in CL infection, probably in accordance with host defense mechanisms. It is indicated that application of
KLV/BCG as a combined vaccine/adjuvant could be indicated as a potent inducer of immuno-biochemical
characters during infection with Leishmaniasis. In conclusion, some dependency is observed between KLV/BCG
and NO levels, Cu, Zn concentrations and SGOT, SGPT production. The mechanism of KLV/BCG action may be
associated more on BCG rather than KLV.
Key words: BCG, immunization, Iran, killed leishmania vaccine, KLV, Leishmania major, ,
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Cite this Reference:
Sara Nemati, Seyedeh Parisa Jafary, Hossein Nahrevanian, Mahin Farahmand and Shahrzad Nahrevanian, . Immuno-Biochemical Alterations in Leishmania major Infected Balb/c Mice after Immunization with Killed Leishmania Vaccine and BCG as Adjuvant. Current Research Journal of Biological Sciences, (6): 706-712.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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