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Abstract
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Article Information:
“An Immunohistochemical Study” of Parathyroid Hormone - Related Protein: A Comparative Analysis In Ameloblastoma and Dentigerous Cyst
K. Shyamala and S. Hemavathy
Corresponding Author: Shyamala Karnam
Submitted: 2010 May, 22
Accepted: 2010 June, 14
Published: 2010 July, 20 |
Abstract:
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It has been pointed out that Parathyroid Hormone related Protein (PTHrP) secreted by the developing
enamel epithelium targets receptors in overlying bone, thereby activating bone resorption and allowing tooth
eruption. Accordingly, it is conceivable that ameloblastoma, which to a degree recapitulates certain
characteristics of enamel epithelium, would also express PTHrP. This study is done to assess the PTH rP
expression in ameloblastoma, to investigate its role in local bone resorption and provide explanation for the
infiltrative growth and destructive behavior of this tumor which may hold significant therapeutic implications.
A group of 50 histo-pathologically diagnosed, formalin-fixed, paraffin embedded tissue samples, consisting
of 30 samples of am eloblastoma and 20 samples of dentigerous cyst were collected from the Department of
Oral and Maxillofacial Pathology, Govt. Dental College, Bangalore, and were subjected to
immunohistochemical methods using anti PTHrP Antibody with indirect immuno-enzyme Labeled StreptAvidin
Biotin method (LSAB). Out of 30 cases of ameloblastoma 26(86.7%) cases showed positivity for PTHrP.
Among the 20 cases of dentigerous cysts 9(45%) cases showed positivity for PTHrP expression. When we
compared the percentage of cases showing positivity for PTHrP expression in ameloblastoma (86.7%) and
dentigerous cyst (45.0%) we obtained a statistically significant p-value of 0.0012. The current study may
suggest increased PTHrP expression by ameloblastoma may play a significant role in local bone resorption and
may provide explanation for the infiltrative growth and the destructive behavior of this tumor.
Key words: Ameloblastoma, dentigerous cyst, immunohistochemistry, PTHrP, , ,
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Abstract
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Cite this Reference:
K. Shyamala and S. Hemavathy, . “An Immunohistochemical Study” of Parathyroid Hormone - Related Protein: A Comparative Analysis In Ameloblastoma and Dentigerous Cyst. Current Research Journal of Biological Sciences, (4): Page No: 262-267.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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