Methanolic and aqueous grass extracts of Spinifex littoreus (Burm. f.) M err were screened for their antibacterial and antifungal activities. The extracts were tested against 6 different species of human pathogenic bacteria and 4 fungal strains. Most of the extracts were devoid of antifungal and antibacterial activities, the aqueous grass extract of Spinifex littoreus obtained by very good activity when compare to methanol extract, which showed strong inhibitory activity against the Gram-positive and Gram-negative bacteria. This study suggests that aqueous grass extracts of S. littoreus obtained by infusion can be used in the treatm ent of skin diseases caused by dermatophytes.