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2009 (Vol. 1, Issue: 2)
Article Information:

Effect of Aqueous Garlic (Ag) Extract on Aspirin Induced Gastric Mucosal Lesion in Albino Wistar Rats

M.A. Mabrouk, F.I. Nnawodu, Y. Tanko, F. Dawud and A. Mohammed
Corresponding Author:  Mohammed Aliyu 

Key words:  Antioxidant,, garlic extract,, gastric secretion,, gastric ulcer, , ,
Vol. 1 , (2): Page No: 15-19
Submitted Accepted Published
2009 June, 09 2009 July, 15
Abstract:

The aim of this study was to evaluate the effect of aqueous garlic (AG) extract on aspirin induced gastric mucosal lesion. It was carried out on 72 albino Wistar rats. Animals were divided into two groups. Gastric ulcer group (n=36) and gastric secretion group (n=36). Each group was subdivided into control (n=16) and study groups (n=18). Control group was further subdivided into 3 subgroups including (1) Oral distilled water subgroup (n=6); (2) Oral aspirin (150mg/kg) subgroup (n=6) and (3) Oral AG extract (150mg/kg) subgroup (n=6).The study group was also subdivided into (1) Oral aspirin (150mg/Kg) + AG extract (150mg/kg) subgroup(n=6); (2) Oral aspirin (150mg/Kg) + AG extract(300mg/kg) subgroup(n=6) and (3)Oral aspirin(150 mg/kg) + Cemitidine(50mg/kg) I.P subgroup((n=6).All groups were fasted for 36 hours before pyloric ligation. Gastric secretions were collected, centrifuged and analysed.Gastric ulcer parameters were also studied for gastric ulcer group. There was significant decrease(p<0.05) of titratable acidity and total acid output in aspirin(150mg/Kg) + AG (150mg/Kg) and aspirin(150mg/Kg) + AG (300mg/kg) when compared with aspirin(150mg/Kg) alone group. Also there was significant decrease (p<0.05) in ulcer index and ulcer score in both groups than aspirin alone group. In comparison between garlic groups and cemitidine group there was more decrease in these parameters in cemitidine groups than garlic group. It seem s likely that AG extract offered protective effects on aspirin induced gastric mucosal lesion.
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  Cite this Reference:
M.A. Mabrouk, F.I. Nnawodu, Y. Tanko, F. Dawud and A. Mohammed, 2009. Effect of Aqueous Garlic (Ag) Extract on Aspirin Induced Gastric Mucosal Lesion in Albino Wistar Rats.  Current Research Journal of Biological Sciences, 1(2): Page No: 15-19.
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ISSN (Print):   2041-076X
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