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Abstract
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Article Information:
Production of Induced Pluripotent Stem Cells by Reprogramming of Blood Cells
Sadia Zia, Muhammad Zubair Yousaf, Masroor Ellahi Babar
Corresponding Author: Sadia Zia
Submitted: 2011 April, 12
Accepted: 2011 May, 18
Published: 2011 June, 10 |
Abstract:
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Blood cells are the simple, efficient and economical source for the production of induced pluripotent
cells. The discovery of induced pluripotent cells was not novel; it was pedestal on the scientific principals and
technologies which have been developed over last six decades. These are nuclear transfer and the cloning of
Animals, Pluripotent cell lines and fusion hybrids and Transcription Factors and lineage switching. The use of
human embryonic stem cells in regenerative medicines was a breakthrough but make use of these cells arise
ethical issues as they are obtained from human embryos. An alternative advancement using induced pluripotent
stem cells, which mimics the embryonic stem cells has the significant gain that they replaced the embryonic
stem cells. The pluripotent cells can be induced from terminally differentiated somatic cells by the Induction
of only four defined factors including c-Myc, klf4, Oct4 and Sox2 which are enough to alter the fate of cell.
Key words: Fibroblasts, C-Myc, dedifferentiation, iPSCs, blood cells, induced pluripotency, proliferation, reprogramming, transcription factors
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Cite this Reference:
Sadia Zia, Muhammad Zubair Yousaf, Masroor Ellahi Babar, . Production of Induced Pluripotent Stem Cells by Reprogramming of Blood Cells. International Journal of Animal and Veterinary Advances, (3): 193-195.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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