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Abstract
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Article Information:
Hepatoprotective Activity of Aqueous Acetone Extract from Cienfuegosia digitata Cav. (Malvaceae) Against Alcohol Hepatotoxicity in Albinos Wistar Rats
K. Konaté, M. Ouédraogo, M.B. Ouattara, I.C. Dibala, J.F. Mavoungou, A.N. Lepengué, A. Souza, B.M. Batchi and O.G. Nacoulma
Corresponding Author: Konaté Kiessoun
Submitted: February 04, 2011
Accepted: March 08, 2011
Published: June 15, 2012 |
Abstract:
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The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract
of Cienfuegosia digitata Cav. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally liver
disease in albinos Wistar rats. Animals received by gavage 25, 50 and 100 mg/kg body weight of extract daily
for a period of 28 days. Control groups received alcohol 35% and water. In vivo administration of 35% ethanol
for a period of 28 days in rats showed an activity of liver marker enzymes (AST, ALT, ALP and GGT),
triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum compared with rats which received
water (control water). However, administration of 35% ethanol along with aqueous acetone extract decreased
the activities of liver markers enzyme in serum comparatively to the control water group (p<0.05 or p<0.01).
We noticed that extract at a dose of 100 mg/kg body weight was highly effective than 25 and 50 mg/kg body
weight compared to the control water group (ALT and ALP; p>0.05 and p<0.05). This study revealed that
Cienfuegosia digitata presents a hepatoprotective potential and this plant could be traditionally exploited in the
treatment of liver disease particularly hepatitis B in Burkina Faso.
Key words: Cienfuegosia digitata Cav, biochemical parameters, hepatoprotective activity, Albinos Wistar rats, alcohol, Hepatotoxicity,
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Cite this Reference:
K. Konaté, M. Ouédraogo, M.B. Ouattara, I.C. Dibala, J.F. Mavoungou, A.N. Lepengué, A. Souza, B.M. Batchi and O.G. Nacoulma, . Hepatoprotective Activity of Aqueous Acetone Extract from Cienfuegosia digitata Cav. (Malvaceae) Against Alcohol Hepatotoxicity in Albinos Wistar Rats. Research Journal of Applied Sciences, Engineering and Technology, (12): 1637-1641.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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