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2012 (Vol. 4, Issue: 23)
Article Information:

Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats

Ojo Rotimi Johnson, Memudu Adejoke Elizabeth, Akintayo Christopher Oloruntoba and Akpan Idongesit Sunday
Corresponding Author:  Ojo Rotimi Johnson 

Key words:  Alloxan , diabetes, garlic, pre-induction, pre-treatment, serum enzymes, serum enzymes
Vol. 4 , (23): 5129-5135
Submitted Accepted Published
April 07, 2012 April 30, 2012 December 01, 2012
Abstract:

The aim of the present study was to investigate the effects of pre- and post- administration of garlic extract on serum glucose and some biochemical parameters in alloxan-induced diabetic rats to show the preventive and ameliorating effects in alloxan induced-diabetic rats. Rats were divided into 4 groups; normal control rats, diabetic control rats, diabetic rats post-treated with garlic extract and rats pre-treated with garlic extract before induction. Garlic extract was administered orally for 2 weeks to post-treated rats and 3 weeks to pre-treated rats and they were compared with the normal and diabetic groups, respectively. Serum glucose was reduced significantly in both post-treated and pre-treated groups. The post-treatment with garlic extract reduced serum cholesterol, but pre-treatment with garlic extract produced significant change compare to the diabetic control. The serum creatinine and urea levels were significantly reduced in post-treated group and pretreated group compare to the diabetic control group. It is concluded that the consumption of garlic produced a significant hypoglycaemic and hypolipidemic effects in diabetic rats and also, garlic is capable of protecting the liver and the kidney functions in alloxan-induced diabetic rats as shown in the activities of serum enzymes and other biochemical parameters examined.
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  Cite this Reference:
Ojo Rotimi Johnson, Memudu Adejoke Elizabeth, Akintayo Christopher Oloruntoba and Akpan Idongesit Sunday, 2012. Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats.  Research Journal of Applied Sciences, Engineering and Technology, 4(23): 5129-5135.
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