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Abstract
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Article Information:
Phytochemical Constituents and Effect on Haematological Parameters and Lipid Profile of Aqueous Extracts of Eugenia jambolana Leaves, Stem Bark and Root Bark in Normal Albino Rats
O.A. Owolabi, D.B. James, E.B. Adejor, N.Q. Nwaozuzu, T. Oloba and C.D. Luca
Corresponding Author: E.B. Adejor
Submitted: November 19, 2012
Accepted: January 14, 2013
Published: July 20, 2013 |
Abstract:
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This study was designed to investigate the effect of Eugenia jambolana This study was designed to investigate the effect of Eugenia jambolana were screened for phytochemicals and its effect on haematological parameters and lipid profile in normal albino rats were investigated. Twenty four Albino rats weighing between 150-200 kg body weights were divided into four groups of six rats each. Group 1 served as control while groups 2, 3 and 4 were administered (50 mg/kg body weight) of leaves, stem bark and root bark respectively for 21 days. Preliminary phytochemical screening revealed the presence of saponins, alkaloids, flavonoids, cardiac glycosides, tannins and carbohydrates and quantitative analysis by gravimetric method showed significantly (p<0.5) higher levels of saponins and alkaloids in the aqueous extracts of leaves and root bark respectively. The aqueous extracts (leaves, stem bark and root bark) had no significant (p>0.05) effect on haematological parameters. Aqueous extracts of the root bark significantly (p<0.5) increased TC, TG and LDL-c levels and the stem bark extract significantly (p<0.05) reduced HDL-c compared to the control. All three aqueous extracts significantly (p<0.05) lowered HDL-c/TC ratio, the root bark significantly (p<0.05) increased LDL-c/HDL-c ratio and both aqueous extracts of stem bark and root bark significantly (p<0.05) increased log (TG/HDL-c) of treated groups when compared to control.
Key words: Albino rats, atherogenic factors, Eugenia jambolana, Haematological, lipid profile, ,
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Cite this Reference:
O.A. Owolabi, D.B. James, E.B. Adejor, N.Q. Nwaozuzu, T. Oloba and C.D. Luca, . Phytochemical Constituents and Effect on Haematological Parameters and Lipid Profile of Aqueous Extracts of Eugenia jambolana Leaves, Stem Bark and Root Bark in Normal Albino Rats . Research Journal of Applied Sciences, Engineering and Technology, (10): 1846-1850.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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