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Abstract
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Article Information:
Phytopharmacological Assessment from Two Medicinal Plants Used for Analgesic and Anti-inflammatory Purposes in Burkina Faso
M. Ouédraogo, K. Konaté, P. Zerbo, N. Barro and Laya L. Sawadogo
Corresponding Author: M. Ouédraogo
Submitted: November 19, 2012
Accepted: January 01, 2013
Published: July 25, 2013 |
Abstract:
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The purpose of this investigation was to elucidate the anti-nociceptive and anti-inflammatory properties of aqueous acetone extracts from Cienfuegosia digitata Cav; and Sida Alba L. in Swiss mice, with an aim to provide a scientific basis for the traditional use of these plants in the treatment of inflammation disorders. In anti-inflammatory activity, the carrageenan-induced paw edema and oil croton-induced ear edema in Swiss mice. As for analgesic effects, acetic acid writhing and formalin test methods were used in mice. About anti-inflammatory potential, the extracts at doses of 100; 200 and 400 mg/kg body weight produced significant comparatively to the control groups (p<0.05; p<0.01 and p<0.001) and we noticed a dose-dependent anti-inflammatory activity. The dose-dependent inhibition of edema was observed at 1; 2 and 3 h. However, extracts showed dose-dependent inhibition of croton oil induced ear oedema, at doses of 200; 300 and 500 µg/ear. As for analgesic activity, extracts produced significant analgesic effects in acetic acid writhing and formalin test method (p<0.05; p<0.01 and p<0.001) compared to the control groups and a dose-dependent inhibition was observed. The present study concludes that Cienfuegosia digitata Cav. and Sida Alba L. have anti-inflammatory and analgesic properties.
Key words: Analgesic, Cienfuegosia digitata cav.,, inflammation, mice, Sida Alba L, ,
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Cite this Reference:
M. Ouédraogo, K. Konaté, P. Zerbo, N. Barro and Laya L. Sawadogo , . Phytopharmacological Assessment from Two Medicinal Plants Used for Analgesic and Anti-inflammatory Purposes in Burkina Faso. Research Journal of Applied Sciences, Engineering and Technology, (11): 1956-1962.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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