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2014 (Vol. 7, Issue: 2)
Article Information:

Comparing Betamethasone and Dexamethasone Effects on Concentration of Male Reproductive Hormones in Mice

Jalalaldin Gooyande, Mehrdad Modaresi and Akbar Pirestani
Corresponding Author:  Jalalaldin Gooyande 

Key words:  Betamethasone, Dexamethasone, FSH, LH, mice, testosterone,
Vol. 7 , (2): 413-416
Submitted Accepted Published
May 05, 2013 June 04, 2013 January 10, 2014
Abstract:

Most of chemical drugs have side effects on various parts of body. It is necessary to identify these effects to better use of drugs. Betamethasone and Dexamethasone are two of the most usual drugs in human and animal medication. The effect of these drugs on concentration of male reproductive hormones of mice was the goal of this study. Eighteen matured male mice were divided into eight groups including control, placebo and six treatment groups. Placebo group was received physiological serum only and treatments were Betamethasone (0.1, 0.5 and 1 mg/kg) and Dexamethasone (0.1, 0.5 and 1 mg/kg) which were injected in peritoneum every other day and for twenty days. After 20 days, blood samples were taken and FSH, LH and testosterone levels were measured using Eliza test method. Obtained data were analyzed using one way analysis of variance and mean comparison was done using Duncan's multiple ranges test and SPSS program. Results showed that 0.5 mg/kg of Betamethasone and all levels of dexamethasone caused significant increase in FSH concentration. For LH hormone, 1 mg/kg of Betamethasone and 0.1 mg/kg of Dexamethasone caused significant decrease whereas 1 mg/kg of Dexamethasone increased it significantly. Testosterone was increased significantly by 1 mg/kg of Dexamethasone. So, mentioned drugs are effective on hormone action of reproductive system dose dependently and probable effect of them must be considered in time of using.
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  Cite this Reference:
Jalalaldin Gooyande, Mehrdad Modaresi and Akbar Pirestani, 2014. Comparing Betamethasone and Dexamethasone Effects on Concentration of Male Reproductive Hormones in Mice.  Research Journal of Applied Sciences, Engineering and Technology, 7(2): 413-416.
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ISSN (Online):  2040-7467
ISSN (Print):   2040-7459
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