The study sought to find out whether salt residue (Gypsum) that goes waste and poses a threat to the environment could be used to produce Plaster of Paris (P.O.P). Ghana is endowed with natural resources including salt mining of which Sege Salt Mining is of no exception. There is abundant by-product (salt residue). However, it appears the salt residue could be utilized to manufacture Plaster of Paris (P.O.P) locally to feed institutions, agencies and industries that use POP as the main raw material; thereby minimizing the importation of foreign POP. The experimental research method was employed. Sample of the salt residue was obtained from Sege in the Dangme East District of the Greater Accra Region. The salt residue was heated between 120-150°C and crushed into powdered form using corn mill; turning it into POP. The results of the study revealed that the locally produced POP could serve the same purpose as the foreign one. It was recommended, among others, that the by-product could be used to manufacture local POP in order not to pollute the environment with the salt residue.