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     Advance Journal of Food Science and Technology


Effect of Total Flavonoids of Flos Sophorae on Glucose Levels, Serum Lipid and Antioxidation Ability in Diabetic Rats Model

M.S. Miao, Y. Li, T. Wang, S. Shao, S.X. Feng and Y.Y. Miao
Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450046, China
Advance Journal of Food Science and Technology  2016  12:663-666
http://dx.doi.org/10.19026/ajfst.12.3326  |  © The Author(s) 2016
Received: August ‎3, ‎2015  |  Accepted: October ‎11, ‎2015  |  Published: December 25, 2016

Abstract

Objective: To investigate the effect of Total Flavonoids of Sophorae Flos (TFSF) on Glucose Levels, Serum Lipid and antioxidation ability in diabetic rats model which was established by streptozotocin. Method: The diabete rat model was established by injected with streptozotocin, which were fed with high dosage TFSF, medium dosage TFSF, low dosage TFSF, metformin and Physiological saline, another healthy rats were divided into blank group. All the rats were administrated once a day for 30 days. Blood Glucose (BG) in the limosis were measured on the tenth and twentieth day. On the thirtieth day the levels of BG, serum total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, MDA and SOD were measured. Results: Has obvious effect of reducing blood glucose of different doses of TFSF on streptozotocin-induced hyperglycemic rats, which can reduce the levels of serum total cholesterol, triglycerides, low-density lipoprotein, significantly higher the levels of serum high density lipoprotein and MDA, increased SOD antioxidation ability. Conclusion: The TFSF can lower blood sugar and blood lipid efficacy might be related with the increased antioxidant capacity.

Keywords:

Antioxidation ability, Blood Glucose (BG), diabetic, serum lipid, streptozotocin, Total Flavonoids of Flos Sophorae (TFSF),


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Competing interests

The authors have no competing interests.

Open Access Policy

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Copyright

The authors have no competing interests.

ISSN (Online):  2042-4876
ISSN (Print):   2042-4868
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