Abstract

The present study aims to discuss the reference safety of the Brown Rice Starter Red Kojic Rice Wine (BRSRKRW) and provide scientific basis for rational development and utilization of the wine. In order to evaluate the toxicity of BRSRKRW in vivo, acute and subchronic toxicity of BRSRKRW in SD rats by intraperitoneal injections were evaluated. In this acute study, doses of BRSRKRW at 1, 1.5, 2, 2.5, or 31.5, 3 and 6 g/kg.bw, were administered. No adverse effects were observed during a 14-day period and at gross histopathological examination. In the subchronic study, BRSRKRW at 1.5, 3 and 6 g/kg.bw were administered for 30 days. The results showed that BRSRKRW did not affect weight gain in growing rats, in the level of hematological parameters, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, blood urea nitrogen, creatinine, uric acid in blood and histopathological damages of the liver. Overall, the study suggests that the risk of drinking BRSRKRW toxicity to mammals is not negligible.

Keywords:

Acute toxicity, brown rice starter red kojic rice wine, food safety, genetic toxicity, subacute toxicity,

References

1. Becker, D.J., R.Y. Gordon, S.C. Halbert, B. French, P.B. Morris and D.J. Rader, 2009. Red yeast rice for dyslipidemia in statin-intolerant patients: A randomized trial. Ann. Intern. Med., 150: 830-839.
   CrossRef    PMid:19528562    
2. Chang, J.C., M.C. Wu and I.M. Liu, 2006. Plasma glucose-lowering action of Hon-Chi in streptozotocin-induced diabetic rats. Horm. Metab. Res., 38: 76-81.
   CrossRef    PMid:16523406    
3. Erdogrull, O. and S. Azirak, 2004. Review of the studies on the red yeast rice (Monascus purpureus). Turk. Electron. J. Biotech., 2: 37-49.
   
4. Gordon, R.Y., T. Cooperman, W. Obermeyer and D.J. Becker, 2010. Marked variability of monacolin levels in commercial red yeast rice products. Arch. Intern. Med., 170(19): 1722-1727.
   CrossRef    PMid:20975018    
5. Heber, D., I. Yip, J.M. Ashley, D.A. Elashoff, R.M. Elashoff and V.L. Go, 1999. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am. J. Clin. Nutr., 69(2): 231-236.
   CrossRef    PMid:9989685    
6. Komatsuzaki, N., K. Tsukahara, H. Toyoshima, T. Suzuki and N. Shimizu, 2007. Effect of soaking and gaseous treatment on GABA content in germinated brown rice [J]. J. Food Eng., 78(2): 556-560.
   CrossRef    
7. Lin, C.C., T.C. Li and M.M. Lai, 2005. Efficacy and safety of Monascus purpureus Went rice in subjects with hyperlipidemia. Eur. J. Endocrinol, 153: 679-686.
   CrossRef    PMid:16260426    
8. Patil, S.B. and M.K. Khan, 2011. Germinated brown rice as a value added rice product: A review. J. Food Sci. Tech., 48: 661-667.
   CrossRef    PMid:23572802 PMCid:PMC3551059    
9. Venero, C.V., J.V. Venero, D.C. Wortham and P.D. Thompson, 2010. Lipid-lowering efficacy of red yeast rice in a population intolerant to statins. Am. J. Cardiol., 105(5): 664-666.
   CrossRef    PMid:20185013    

Competing interests

The authors have no competing interests.

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