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     Advance Journal of Food Science and Technology


The Effect of a Phaseolus vulgaris and Dietary Fiber Based Supplement on Advanced Glycation End Products: An Open-label Trial

1Brett J. West, 2Laura Kimball, 1Lincoln F. Berrio, 1Laura Robertson and 1C. Jarakae Jensen
1Department of Research and Development
2Product Development, Morinda, Inc., American Fork, Utah 84003, USA
Advance Journal of Food Science and Technology  2015  10:725-729
http://dx.doi.org/10.19026/ajfst.8.1597  |  © The Author(s) 2015
Received: November ‎10, ‎2014  |  Accepted: January ‎8, ‎2015  |  Published: July 10, 2015

Abstract

Elevated Advanced Glycation End product (AGE) levels are associated with certain impaired health states. As these are disruptive to the function of healthy tissues, due to their protein cross-linking ability, AGEs are significant contributors to the aging process. In fact, population studies have revealed that AGE levels tend to increase as we get older. Certain lifestyle and dietary factors may accelerate AGE accumulation. Therefore, strategies intended to modify these factors, or mitigate their effects, may be useful in controlling the aging process. In an 11 week open-label clinical trial, 30 adult volunteers consumed daily a commercially available combination of white kidney bean extract, dietary fibers, &beta-carotene and noni (Morinda citrifolia) fruit pulp, in combination with calorie restriction and exercise. During the course of the trial, participants experienced significant weekly declines in average body weight and fat mass. The average AGE score, as measured by skin auto-fluorescence, had also decreased significantly. In terms of AGE associated years, the change in AGE scores corresponded to an average decrease of 8.83 years. The results indicate that the intervention contributed to improved health and exhibited anti-aging properties.

Keywords:

Advanced glycation end products, dietary fiber, Phaseolus vulgaris extract,


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Competing interests

The authors have no competing interests.

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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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The authors have no competing interests.

ISSN (Online):  2042-4876
ISSN (Print):   2042-4868
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