Home            Contact us            FAQs
    
      Journal Home      |      Aim & Scope     |     Author(s) Information      |      Editorial Board      |      MSP Download Statistics

     Research Journal of Applied Sciences, Engineering and Technology


Mechanism and Kinetics of Novel Coumarin Derivatives Production for Pharmaceutical Applications

Dr. Omar Ismail
Department of Chemistry, Faculty of Science, Hail University, P.O. Box 2440, Hail, Saudi Arabia
Research Journal of Applied Sciences, Engineering and Technology   2016  4:452-464
http://dx.doi.org/10.19026/rjaset.12.2385  |  © The Author(s) 2016
Received: September ‎7, ‎2015  |  Accepted: October ‎17, ‎2015  |  Published: February 25, 2016

Abstract

Naturally coumarins have some bioactivity and commonly used among traditional medicine recipes against diabetes and hepatitis diseases. In addition to their derivatives that possess high importance due to their biological activity, therefore they are induced in the pharmaceutical industry as anticoagulant, antimicrobial, anti-inflammatory, antiviral, antioxidant and analgesic compounds. In this study, the formation of coumarin derivatives, which involved in pharmaceutical industries, was passed through by studying their method of preparation, mechanism of their preparative reactions and the study of their rate of reactions. Reactions were demonstrated subsequently by obtaining the product to be obtained for the next one and starting from coumarin synthesis.

Keywords:

Coumarin derivatives, kinetics, mechanism, pharmaceutical applications,


References

  1. Ajani, O.O. and O.C. Nwinyi, 2010. Microwave-assisted synthesis and evaluation of antimicrobial activity of 3-{3-(s-aryl and s-heteroaromatic) acryloyl}-2H-chromen-2-one derivatives. J. Heterocyclic Chem., 47: 179-187.
    CrossRef    
  2. Al-Zaydi, K.M., 2003. Microwave assisted synthesis, part 1: Rapid solventless synthesis of 3-substituted coumarins and benzocoumarins by microwave irradiation of the corresponding enaminones. Molecules, 8(7): 541-555.
    CrossRef    
  3. Atta-Ur-Rahman, A.B. Reitz and M.I. Choudhary, 2009. Frontiers in Medicinal Chemistry. Bentham Science Publishers, Sharjah, 4: 842-882.
  4. Edardes, J.P., 2008. Coumarin Anticoagulant Research Progress. Nova Biomedical Books, Nova Science Poblishers, New York, pp: 1-9.
  5. El-kady, 2002. Studies on Coumarin Derivatives. Ain Shams University, pp: 102-108.
  6. El-kasem, A.O., 2002. Synthesis of some new coumarin derivatives of expected biological activity. Ain Shams Univ., 37: 381.
  7. Kavimani, S., V.M. Mounissamy, R. Gunasegaran, 2000. Analgesic and anti-inflammatory activities ofHispidulir isolated from Helichrysumbracteatum. Indian drugs, 37: 582.
  8. Khadse, C.D. and R.B. Kakde, 2011. Anti-inflammatory activity of aqueous extract fractions of Barleria prionitis L. roots. Asian J. Plant Sci. Res., 1(2): 63-68.
  9. More, P.M., 2011. Indian J. Chem., 3: 747-757.
  10. Murray, R.D.H., J. Mendez and S.A. Brown, 1982. The Natural Coumarins: Ocurrence, Chemistry and Biochemistry, John Wiley and Sons Ltd., New York, pp: 21.
  11. Nachiket, S.D., R.P. Shashikant, S.S. Dengale, D.S. Musmade, M. Shelar, V. Tambe and M. Hole, 2010. Der Pharm. Chem., 2(2): 65-71.
  12. Patil, V.V. and V.R. Patil, 2011. Evaluation of anti-inflammatory activity of Ficus carica Linn. leaves. Indian J. Nat. Prod. Resour., 2(2): 151-155.
  13. Rajasekaran, S., G.K. Rao, S.P.N. Pai and A. Ranjan, 2011. ‘Synthesis of novel coumarin derivatives and its biological evaluations’. Int. J. Chem. Tech. Res., 3(2): 555-559.
  14. Shah, V., N. Shah and P. Shirote, 2011. Advanced Method for Synthesis of Potent Coumarin Derivatives: Design, Synthesis and Pharmacological Screening of Some Coumarin Derivatives. LAP Lambert Academic Publishing, pp: 88.
    PMCid:PMC3693225    
  15. Sharma, V.A., 2011. Coumarin derivative preparation. J. Chem. Pharm., 3(2): 204-212.
  16. Veshik, B., 2011. Issues in Pharmacology, Pharmacy, Drug Research and Drug Innovation: 2011 Edition.

Competing interests

The authors have no competing interests.

Open Access Policy

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Copyright

The authors have no competing interests.

ISSN (Online):  2040-7467
ISSN (Print):   2040-7459
Submit Manuscript
   Information
   Sales & Services
Home   |  Contact us   |  About us   |  Privacy Policy
Copyright © 2024. MAXWELL Scientific Publication Corp., All rights reserved