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     British Journal of Pharmacology and Toxicology


Effects of Mastitis on Pharmacokinetics of Elimination with Milk of BenzimidazoleAnthelmintics

1Alper Sezgin and 2Bunyamin Tras
1Department of Pharmacology and Toxicology, Veterinary Control Institute, Istanbul
2Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Seljuk, Konya, Turkey
British Journal of Pharmacology and Toxicology  2016  3:31-35
http://dx.doi.org/10.19026/bjpt.7.2986  |  © The Author(s) 2016
Received: April ‎17, ‎2016  |  Accepted: July ‎11, ‎2016  |  Published: August 25, 2016

Abstract

The current study was performed to determine the effects of mastitis on behaviour of benzimidazole anthelmintic drugs in milk. Seven Brown Swiss cows with subclinical mastitis infection in one or two udder quarters and not in the first trimester period of pregnancy were used in this study. The study was conducted in cross-over design method. Albendazole (ABZ), triclabendazole (TCBZ) and fenbendazole (FBZ) at 7. 5 mg/kg, 10 mg/kg and 7.5 mg/kg single oral doses were applied to animals with mastitis and after mastitis treatment respectively. The milk and blood samples were collected at prior to drug administration and following drug application zeroth, 8th, 16th, 24th, 36th, 48th, 72nd and 120th hours. The milk and blood samples were extracted with SPE (Solid Phase Extraction) and analysed by HPLC. Mastitis caused only the change in the behaviour of ABZ in milk. AUCmilk/AUCMplasma rates were calculated respectively as 0.96, 0.95, 0.97, 0.92, 0.91 and 0.89 for albendazolesulfoxide (ABZSO), albendazolesulfon (ABZSO2), triclabendazolesulfoxide (TCBZSO), triclabendazolesulfon (TKBZSO2), fenbendazole (FBZ) and fenbendazolesulfoxide (FBZSO) in animals without mastitis. These rates in animals with mastitis were 1.28, 1.21, 0.98, 0.93, 0.97 and 0.94 respectively. While the biological half-life of ABZSO and ABZSO2 were found as 24.01 and 20.92 hour in milk of animals with mastitis, these parameters were 17.49 and 19.77 hour in milk of animals without mastitis. The biological half-life of plasma for ABZSO, ABZSO2, TKBZSO, TKBZSO2, FBZ and FBSO were calculated as 10.55, 9.94, 24.11, 31.75, 14.68, 20.13 and 16.75 hours in healthy animals. Inflammatory diseases such as mastitis may change pharmacokinetic behaviour of some drugs in the milk.

Keywords:

Benzimidazoleanthelmintics, mastitis, pharmacokinetic,


References


Competing interests

The authors have no competing interests.

Open Access Policy

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Copyright

The authors have no competing interests.

ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
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